CORDIS
EU research results

CORDIS

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Regulating nuclear organisation in telomere maintenance and DNA repair: the role of SUMO modification

Project information

Grant agreement ID: 221027

Status

Closed project

  • Start date

    1 March 2008

  • End date

    28 February 2010

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 179 297,73

  • EU contribution

    € 179 297,73

Coordinated by:

Novartis Forschungsstiftung

Switzerland

Objective

The organisation of the genome into separate domains and sub-compartments through higher order chromatin structure is an important means by which eukaryotic cells control nuclear processes such as DNA transcription and repair. Recent evidence has implicated sumoylation as an important regulator of global nuclear architecture as well as allied processes such as telomere maintenance and DNA damage repair. Using the yeast Saccharomyces cerevisiae as a model organism to look at nuclear dynamics in vivo, we aim to elucidate the mechanism by which SUMO modification regulates these processes.
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Coordinator

Novartis Forschungsstiftung

Address

Maulbeerstrasse 66
4058 Basel

Switzerland

Activity type

Research Organisations

EU Contribution

€ 179 297,73

Administrative Contact

Susan Gasser (Prof.)

Project information

Grant agreement ID: 221027

Status

Closed project

  • Start date

    1 March 2008

  • End date

    28 February 2010

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 179 297,73

  • EU contribution

    € 179 297,73

Coordinated by:

Novartis Forschungsstiftung

Switzerland