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Continuous Annular Electro-Chromatography

Objective

Capillary electrochromatography (CEC) combines the high separation efficiency of capillary electrophoresis with high performance liquid chromatography (HPLC) and provides a powerful tool for the separation of a wide range of both neutral and charged components. The proposed integration of this technology and the rotating system of annular chromatography into a continuous annular electrochromatography (CAEC) would increase the throughput up to 20,000 times whilst maintaining an efficiency of more than 100,000 theoretical separation stages per meter. This extends the range of applicability from analytical purposes towards safe and flexible ultra small-scale production of extremely high-value-added products early on in the development stages. The project is thus expected to significantly enhance the sustainability of pharmaceutical and chemical production by providing equipment for highly intensified purification processes. The development of CAEC units as a new generation of extremely flexible high-performance process equipment requires specialised engineering skills and high-precision manufacturing techniques. A wide range of applications will be offered by the development of tailored stationary phases while an improved understanding of the complex processes occurring at different scales is used to model the performance of the CAEC system. An elaborated prototype including on-line sensors and a sophisticated process control concept will be developed and validated under industrial conditions during a demonstration phase. This will guarantee a fast uptake of the projects results and allow for an approved industrial production of the new process equipment within 1 to 2 years after the end of the project. The consortium includes an end user from pharmaceutical industry to ensure the relation to practice as well as highly innovative equipment manufactures capable of producing the required devices and standardised components at affordable costs.

Field of science

  • /natural sciences/chemical sciences/electrochemistry/electrophoresis
  • /social sciences/other social sciences/social sciences interdisciplinary/sustainable development

Call for proposal

FP7-NMP-2007-SMALL-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

TECHNISCHE UNIVERSITAT DORTMUND
Address
August Schmidt Strasse 4
44227 Dortmund
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 665 180
Administrative Contact
Dorota Pawlucka (Ms.)

Participants (7)

TECHNISCHE UNIVERSITAT KAISERSLAUTERN
Germany
EU contribution
€ 371 680
Address
Gottlieb Daimler Strasse
67663 Kaiserslautern
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Berthold Klein (Mr.)
TECHNISCHE UNIVERSITAET GRAZ
Austria
EU contribution
€ 355 538
Address
Rechbauerstrasse 12
8010 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Johannes Khinast (Prof.)
INSTITUT FUER MIKROTECHNIK MAINZ GMBH
Germany
EU contribution
€ 644 189
Address
Carl-zeiss-str. 18-20
55129 Mainz
Activity type
Research Organisations
Administrative Contact
Frank Hainel (Dr.)
MICROINNOVA ENGINEERING GMBH
Austria
EU contribution
€ 258 964
Address
Europapark 1
8412 Allerheiligen Bei Wildon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Dirk Kirschneck (Dr.)
NOVARTIS PHARMA AG
Switzerland
EU contribution
€ 131 228
Address
Lichtstrasse 35
4056 Basel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Berthold Schenkel (Dr.)
TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
EU contribution
€ 196 364
Address
Groene Loper 3
5612 AE Eindhoven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul (P.M.L.O.) Scholte (Dr.)
GALILAEUS OY
Finland
EU contribution
€ 57 000
Address
Kairiskulmantie 10
20781 Kaarina
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Piia Hara (Dr.)