Objective Adenosine receptors are expressed on immune cells and other tissues thought to regulate inflammatory events in mammals. Adenosine receptors, when activated by endogenous ligands or exogenous analogs, may repress inflammatory and immune pathways that lead to the destruction of pancreatic islets in models of type I diabetes and islet graft rejection. Building on our observations that inosine and NECA, two adenosine receptor agonists, inhibit diabetes and islet graft rejection in non-obese diabetic mice and multiple-low-dose-streptozotocin-treated mice, we postulate that certain adenosine receptor subtypes play a protective role in these type 1 diabetic mouse models. There are four types of adenosine receptors, all of which are members of the G protein-coupled family of receptors. The genes for these receptors have been analyzed in detail and they are designated A1, A2A, A2B, and A3. In this proposal we will attempt to delineate the exact roles for the various adenosine receptors in modulating the development of diabetes. By identifying which receptor(s) mediate the adenosine-mediated suppression of diabetes, we can utilize this information to develop new therapeutic approaches that specifically target the receptor(s) of interest. Fields of science medical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicineimmunologynatural sciencesbiological scienceszoologymammalogy Keywords Health sciences Immunology Lymphocyte Macrophage Pharmacological sciences Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) PEOPLE-2007-4-3.IRG - Marie Curie Action: "International Reintegration Grants" Call for proposal FP7-PEOPLE-2007-4-3-IRG See other projects for this call Funding Scheme MC-IRG - International Re-integration Grants (IRG) Coordinator HUN REN KISERLETI ORVOSTUDOMANYI KUTATOINTEZET EU contribution € 75 000,00 Address SZIGONY UTCA 43 1083 Budapest Hungary See on map Region Közép-Magyarország Budapest Budapest Activity type Research Organisations Administrative Contact György Haskó (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
