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Malaria Transmission Blocking by Vaccines, Drugs and Immune Mosquitoes: Efficacy Assessment and Targets

Objective

Malaria is a complex disease, dependent on multiple host/parasite/vector interactions. This tripartite system offers numerous opportunities for disease-preventing interventions, but also creates robustness that undercuts ‘magic bullet’ expectations. Our interdisciplinary TransMalariaBloc will approach the challenge of malaria control in the field from this perspective. It utilizes the enormous recent advances in our molecular understanding of the three implicated organisms without prejudicing which targets or process will prove most suitable to transmission blocking (TB). In a feedback loop of experimentation and modeling, we will address the potential and actual impact of TB drugs and remedies which supplied to human hosts, can block transmission from an infected bloodmeal; TB vaccines which elicit human antibodies to antigens essential for transmission; and immune mosquitoes, genetically modified (GM) to achieve natural or synthetic refractoriness. Recent studies suggest that vector/parasite genotypic interactions determine the success or failure of Plasmodium falciparum to infect mosquitoes. In this perspective, we will assay genome-wide polymorphisms in both parasites and vectors to dissect important genotype*genotype interactions, thus guiding the development of effective TB vaccines, drugs and remedies, and GM mosquitoes. Effectiveness of TB interventions, especially via use of GM mosquitoes, depends on the balance of infection and resistance costs. Components of this balance will be explored, to foresee the dynamics of vectorial competence in mosquito populations and assess the efficacy of TB strategies, as well as guide the development of new targets. Again, interaction between modeling and experimentation will be a powerful combination. This proposal represents an ambitious, but feasible approach, spanning from molecular to population and environmental levels, to optimizing TB interventions for malaria control in endemic areas.

Call for proposal

FP7-HEALTH-2007-B
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Coordinator

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
United Kingdom

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Brooke Alasya (Ms.)
EU contribution
€ 1 190 802

Participants (6)

UNIVERSITA DEGLI STUDI DI CAMERINO
Italy
EU contribution
€ 291 470
Address
Piazza Cavour 19f
62032 Camerino

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ermanno Pieroni (Dr.)
LIVERPOOL SCHOOL OF TROPICAL MEDICINE
United Kingdom
EU contribution
€ 299 108
Address
Pembroke Place
L35QA Liverpool

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Robert Einion Holland (Mr.)
IDRYMA TECHNOLOGIAS KAI EREVNAS
Greece
EU contribution
€ 386 840
Address
N Plastira Str 100
70013 Irakleio

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Activity type
Research Organisations
Administrative Contact
Zinovia Papatheodorou (Ms.)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT
France
EU contribution
€ 311 688
Address
Boulevard De Dunkerque 44 Cs 90009
13572 Marseille

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Activity type
Research Organisations
Administrative Contact
Ariel Crozon (Ms.)
CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE ET TECHNOLOGIQUE*INSTITUT DE RECHERCHE EN SCIENCES DE LA SANTE
Burkina Faso
EU contribution
€ 307 224
Address
B P 7047
03 Ouagadougou

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Activity type
Research Organisations
Administrative Contact
Levy Kaboré (Mr.)
MAKERERE UNIVERSITY
Uganda
EU contribution
€ 206 832
Address
Main Campus
256 Kampala

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vincent Ssembatya (Dr.)