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Novel biofunctional high porous polymer scaffolds and techniques controlling angiogenesis for the regeneration and repair of the degenerated intervertebral disc

Novel biofunctional high porous polymer scaffolds and techniques controlling angiogenesis for the regeneration and repair of the degenerated intervertebral disc

Objective

30% of European workers experience back pain, and it is the most frequently reported work-related disorder. The proposed work seeks to provide a cure for lower back pain by developing porous scaffolds and technology which will repair a damaged intervertebral disc (IVD) by enabling its regeneration to a natural healthy state or better. Injectable acellular and cell-loaded bioactive polymer-based scaffolds will be developed. These will be designed to be implanted into the patient by minimally invasive surgery. A biomimetic approach will confer the appropriate mechanical and biological properties and enable the inclusion of the requisite cell signalling factors to produce a bio-hybrid structure which closely resembles the human tissue in all its essential attributes. Particular attention will be paid to angiogenesis. In IVD tissue, vascularization must be carefully controlled, due to the unique anatomy and physiology of the intervertebral disc. There must be negligible vascularization in the annulus and nucleus regions and moderate vascularization at the vertebral body level. Work will therefore be performed on materials functionalization, and on growth factor incorporation and delivery, to enable this region-specific control of vascularization at different levels. Natural IVD tissue contains a relatively low number of cells, which are chondrocyte-like in character. Consequently, it will be necessary to devote some research to identifying and evaluating suitable and more readily available alternative cells for incorporation in the bio-hybrid substitutes produced . Modelling studies will identify the physical and mechanical properties of the natural IVD and the substitute materials, and provide an understanding of the physical aspects of the regeneration process. In vivo study on animal model will be performed the bio-fuctionality of both sustitutes. Surgical methodology and protocol will be developed.
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Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE

Address

Piazzale Aldo Moro 7
00185 Roma

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 977 431

Administrative Contact

Luigi Ambrosio (Prof.)

Participants (16)

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ANIKA THERAPEUTICS SRL

Italy

EU Contribution

€ 527 501

UNIVERSITATSSPITAL BASEL

Switzerland

EU Contribution

€ 427 080

UNIVERSITY OF BRIGHTON

United Kingdom

EU Contribution

€ 342 094

INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA

Portugal

EU Contribution

€ 434 500

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA

Spain

EU Contribution

€ 269 500

RISE IVF AB

Sweden

EU Contribution

€ 311 256

NATIONAL UNIVERSITY OF IRELAND GALWAY

Ireland

EU Contribution

€ 318 250

UNIVERSITAET ULM

Germany

EU Contribution

€ 522 000

UNIVERSIDAD DE ALICANTE

Spain

EU Contribution

€ 318 058

UNIVERSITA DEGLI STUDI DI PADOVA

Italy

EU Contribution

€ 295 742

UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Romania

EU Contribution

€ 310 750

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 438 000

UNIVERSIDADE DO MINHO

Portugal

EU Contribution

€ 422 000

SOCIETA AZIONARIA MATERIALE OSPEDALIERO SAMO SPA

Italy

EU Contribution

€ 327 440

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 263 500

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ

Germany

EU Contribution

€ 472 048

Project information

Grant agreement ID: 213904

Status

Closed project

  • Start date

    1 November 2008

  • End date

    31 October 2012

Funded under:

FP7-NMP

  • Overall budget:

    € 9 422 854

  • EU contribution

    € 6 977 150

Coordinated by:

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

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