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Angiogenesis-inducing Bioactive and Bioresponsive Scaffolds in Tissue Enginering

Objective

Angiogenesis underlies almost all biological processes of morphogenesis, including those in tissue repair and regeneration. Physiological angiogenesis is controlled by a complex interplay between cells and their environment: the extracellular matrix (ECM) provides signaling via numerous ECM adhesion molecules and growth factors bound to ECM polysaccharide components; and cells locally degrade and remodel the ECM to create pores into which angiogenic endothelial cells migrate. This observation, that physiological angiogenesis proceeds in response to solid-phase cues motivates our approach, namely creating bioactive resorbable materials as scaffolds that contain bound molecular signals to induce physiological angiogenesis in situations of tissue repair and regeneration. In some of our scaffold materials, porosity is inherent by virtue of fabrication, and in others porosity is created by cell-associated proteolysis as it is in physiological angiogenesis. All materials will be designed so as to be injectable or implantable into the human body. In some work, the final injectable/implantable material will comprise only materials and bioactive biomolecular signals, and in other cases it will also comprise cells. Thus, the concept of ANGIOSCAFF is to create materials that are bioresponsive (to environmental signals including pH and redox potential, and to cellular signals such as proteases), that are bioactive (by virtue of bound peptide or recombinant protein adhesion ligands and bound and releasable growth factors), and that are capable of carrying cellular therapeutics. To realize ANGIOSCAFF, we have assembled a team comprising both industrial and academic expert groups in biomaterials design and development, experts in the science and application of angiogenesis, in imaging in animal models, and in applications demanding biomaterials-based, angiogenesis-demanding tissue engineering therapies, including repair of bone, skin, cardiac muscle, skeletal muscle and nerve.

Field of science

  • /medical and health sciences/medical biotechnology/tissue engineering
  • /natural sciences/biological sciences/biochemistry/biomolecules/carbohydrates
  • /engineering and technology/industrial biotechnology/biomaterials

Call for proposal

FP7-NMP-2007-LARGE-1
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Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 267 213,54
Administrative Contact
Christina Mattsson (Ms.)

Participants (32)

UPPSALA UNIVERSITET
Sweden
EU contribution
€ 393 629,30
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yvonne Brandt Andersson (Prof.)
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain
EU contribution
€ 407 464,58
Address
Carrer Baldiri Reixac Planta 2A 10-12
08028 Barcelona
Activity type
Research Organisations
Administrative Contact
Josep Planell (Prof.)
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel
EU contribution
€ 752 067,10
Address
Senate Building Technion City
32000 Haifa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mark Davison (Mr.)
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 352 375,20
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Cartledge (Mr.)
LEIBNIZ-INSTITUT FUR POLYMERFORSCHUNG DRESDEN EV
Germany
EU contribution
€ 426 071,57
Address
Hohe Strasse 6
01069 Dresden
Activity type
Research Organisations
Administrative Contact
Sandra Boerner (Ms.)
UNIVERSITATSSPITAL BASEL
Switzerland
EU contribution
€ 350 035,80
Address
Hebelstrasse 32
4031 Basel
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Caroline Jaussi (Ms.)
IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE
Italy
EU contribution
€ 271 520
Address
Via Adamello 16
20139 Milano
Activity type
Research Organisations
Administrative Contact
Raffaela Zoboli (Ms.)
JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Germany
EU contribution
€ 364 529,45
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rolf Draeger (Mr.)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 428 405,83
Address
Ramistrasse 71
8006 Zürich
Activity type
Other
Administrative Contact
Andreas Zisch (Prof.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 345 123,53
Address
Calle Serrano 117
28006 Madrid
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Research Organisations
Administrative Contact
Mar García-Ferrer (Ms.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 433 668,12
Address
Raemistrasse 101
8092 Zuerich
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Higher or Secondary Education Establishments
Administrative Contact
Ralph Mueller (Prof.)
UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 462 364,05
Address
Albertus Magnus Platz
50931 Koeln
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Higher or Secondary Education Establishments
Administrative Contact
Jutta Landvogt (Ms.)
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 425 794,96
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Neumann (Dr.)
LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG
Austria
EU contribution
€ 514 865,78
Address
Nussdorfer Strasse 64/6
1090 Wien
Activity type
Research Organisations
Administrative Contact
Juan Cabello (Mr.)
FONDAZIONE PARCO BIOMEDICO SAN RAFFAELE

Participation ended

Italy
EU contribution
€ 157 108,40
Address
Via Castel Romano 100
00128 Roma
Activity type
Research Organisations
Administrative Contact
Domenico Pecorini (Prof.)
IRCCS OSPEDALE POLICLINICO SAN MARTINO
Italy
Address
Largo Rosanna Benzi 10
16132 Genova
Activity type
Research Organisations
Administrative Contact
Piera Castagnacci (Ms.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 383 514,62
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dawn Barker (Ms.)
NEWRON SWEDEN AB
Sweden
EU contribution
€ 87 600
Address
Fiskartorpsvagen 15 A D
114 33 Stockholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Henrik Resmark (Dr.)
BIO-HYOS AB
Sweden
EU contribution
€ 353 518,80
Address
Virdings Alle 32 B
754 50 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jim Akerblom (Dr.)
BIORIGEN SRL
Italy
EU contribution
€ 327 564,59
Address
Via De Marini 1 7Th Floor
16149 Genova
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nicolas Zaghini (Dr.)
DANDO WEISS & COLUCCI LIMITED
United Kingdom
EU contribution
€ 338 566,46
Address
Lower Bristol Road Minerva House
BA2 9ER Bath
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jeffrey Dando (Mr.)
INTERCYTEX LTD
United Kingdom
EU contribution
€ 70 418,18
Address
Crewe Road Innovation House
M23 9QR Manchester
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Richard Moulson (Mr.)
KUROS BIOSURGERY AG
Switzerland
EU contribution
€ 364 590,15
Address
Technoparkstrasse 1
8005 Zurich
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Didier Cowling (Mr.)
MILTENYI BIOTEC GMBH
Germany
EU contribution
€ 203 889,42
Address
Friedrich Ebert Strasse 68
51429 Bergish Gladbach
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Michael Apel (Dr.)
BAXALTA INNOVATIONS GMBH
Austria
EU contribution
€ 34 800
Address
Industriestrasse 67
1221 Wien
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Johannes Regenbogen (Dr.)
SMITH & NEPHEW UK LIMITED
United Kingdom
EU contribution
€ 8 088,60
Address
Adam Street 15
WC2N 6LA London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Rob Yates (Mr.)
BAYER INNOVATION GMBH
Germany
EU contribution
€ 1 731,14
Address
Merowinger Platz 1
40225 Dusseldorf
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Burkhard Fugmann (Dr.)
FONDAZIONE MULTIMEDICA ONLUS
Italy
EU contribution
€ 259 494,20
Address
Via Fantoli 16/15
20138 Milano
Activity type
Research Organisations
Administrative Contact
Daniela Sperti (Ms.)
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR

Participation ended

Italy
EU contribution
€ 116 762,96
Address
Via Olgettina 60
20132 Milano
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Research Organisations
Administrative Contact
Mario Valsecchi (Mr.)
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italy
EU contribution
€ 224 984,71
Address
Piazzale Aldo Moro 5
00185 Roma
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Higher or Secondary Education Establishments
Administrative Contact
Giancarlo Bertea (Dr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 128 063,30
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
ISTITUTO NAZIONALE PER LA RICERCA SUL CANCRO

Participation ended

Italy
EU contribution
€ 375 415,66
Address
Largo Rosanna Benzi 10
16132 Genova
Activity type
Research Organisations
Administrative Contact
Piera Castagnacci (Ms.)