Objective Angiogenesis underlies almost all biological processes of morphogenesis, including those in tissue repair and regeneration. Physiological angiogenesis is controlled by a complex interplay between cells and their environment: the extracellular matrix (ECM) provides signaling via numerous ECM adhesion molecules and growth factors bound to ECM polysaccharide components; and cells locally degrade and remodel the ECM to create pores into which angiogenic endothelial cells migrate. This observation, that physiological angiogenesis proceeds in response to solid-phase cues motivates our approach, namely creating bioactive resorbable materials as scaffolds that contain bound molecular signals to induce physiological angiogenesis in situations of tissue repair and regeneration. In some of our scaffold materials, porosity is inherent by virtue of fabrication, and in others porosity is created by cell-associated proteolysis as it is in physiological angiogenesis. All materials will be designed so as to be injectable or implantable into the human body. In some work, the final injectable/implantable material will comprise only materials and bioactive biomolecular signals, and in other cases it will also comprise cells. Thus, the concept of ANGIOSCAFF is to create materials that are bioresponsive (to environmental signals including pH and redox potential, and to cellular signals such as proteases), that are bioactive (by virtue of bound peptide or recombinant protein adhesion ligands and bound and releasable growth factors), and that are capable of carrying cellular therapeutics. To realize ANGIOSCAFF, we have assembled a team comprising both industrial and academic expert groups in biomaterials design and development, experts in the science and application of angiogenesis, in imaging in animal models, and in applications demanding biomaterials-based, angiogenesis-demanding tissue engineering therapies, including repair of bone, skin, cardiac muscle, skeletal muscle and nerve. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesmedical biotechnologytissue engineeringnatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydratesengineering and technologyindustrial biotechnologybiomaterials Keywords Biomaterial angiogenesis cell transplantation growth factors scaffold therapeutics Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2007-2.3-1 - Highly porous bioactive scaffolds favouring angiogenesis for tissue engineering Call for proposal FP7-NMP-2007-LARGE-1 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE EU contribution € 2 267 213,54 Address BATIMENT CE 3316 STATION 1 1015 Lausanne Switzerland See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Christina Mattsson (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (32) Sort alphabetically Sort by EU Contribution Expand all Collapse all UPPSALA UNIVERSITET Sweden EU contribution € 393 629,30 Address VON KRAEMERS ALLE 4 751 05 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Higher or Secondary Education Establishments Administrative Contact Yvonne Brandt Andersson (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA Spain EU contribution € 407 464,58 Address CARRER BALDIRI REIXAC PLANTA 2A 10-12 08028 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Josep Planell (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY Israel EU contribution € 752 067,10 Address SENATE BUILDING TECHNION CITY 32000 Haifa See on map Activity type Higher or Secondary Education Establishments Administrative Contact Mark Davison (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF NOTTINGHAM United Kingdom EU contribution € 352 375,20 Address University Park NG7 2RD Nottingham See on map Region East Midlands (England) Derbyshire and Nottinghamshire Nottingham Activity type Higher or Secondary Education Establishments Administrative Contact Paul Cartledge (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LEIBNIZ-INSTITUT FUR POLYMERFORSCHUNG DRESDEN EV Germany EU contribution € 426 071,57 Address HOHE STRASSE 6 01069 Dresden See on map Region Sachsen Dresden Dresden, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Sandra Boerner (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITATSSPITAL BASEL Switzerland EU contribution € 350 035,80 Address HEBELSTRASSE 32 4031 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Caroline Jaussi (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS Italy EU contribution € 271 520,00 Address VIA ADAMELLO 16 20139 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Raffaela Zoboli (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN Germany EU contribution € 364 529,45 Address THEODOR W ADORNO PLATZ 1 60323 Frankfurt Am Main See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Rolf Draeger (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data University of Zurich Switzerland EU contribution € 428 405,83 Address RAMISTRASSE 71 8006 ZURICH See on map Activity type Higher or Secondary Education Establishments Administrative Contact Andreas Zisch (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 345 123,53 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Mar García-Ferrer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 433 668,12 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Ralph Mueller (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT ZU KOLN Germany EU contribution € 462 364,05 Address ALBERTUS MAGNUS PLATZ 50931 Koln See on map Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Jutta Landvogt (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Germany EU contribution € 425 794,96 Address Martinistrasse 52 20251 Hamburg See on map Region Hamburg Hamburg Hamburg Activity type Higher or Secondary Education Establishments Administrative Contact Frank Neumann (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LUDWIG BOLTZMANN GESELLSCHAFT OSTERREICHISCHE VEREINIGUNG ZUR FORDERUNG DER WISSENSCHAFTLICHEN FORSCHUNG Austria EU contribution € 514 865,78 Address NUSSDORFER STRASSE 64/6 1090 Wien See on map Region Ostösterreich Wien Wien Activity type Research Organisations Administrative Contact Juan Cabello (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDAZIONE PARCO BIOMEDICO SAN RAFFAELE Participation ended Italy EU contribution € 157 108,40 Address VIA CASTEL ROMANO 100 00128 ROMA See on map Activity type Research Organisations Administrative Contact Domenico Pecorini (Prof.) Links Contact the organisation Opens in new window Total cost No data IRCCS OSPEDALE POLICLINICO SAN MARTINO Italy EU contribution No data Address LARGO ROSANNA BENZI 10 16132 Genova See on map Region Nord-Ovest Liguria Genova Activity type Research Organisations Administrative Contact Piera Castagnacci (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 383 514,62 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Dawn Barker (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NEWRON SWEDEN AB Sweden EU contribution € 87 600,00 Address FISKARTORPSVAGEN 15 A D 114 33 STOCKHOLM See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Henrik Resmark (Dr.) Links Contact the organisation Opens in new window Total cost No data BIO-HYOS AB Sweden EU contribution € 353 518,80 Address VIRDINGS ALLE 32 B 754 50 UPPSALA See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jim Akerblom (Dr.) Links Contact the organisation Opens in new window Total cost No data BIORIGEN SRL Italy EU contribution € 327 564,59 Address VIA DE MARINI 1 7TH FLOOR 16149 Genova See on map Region Nord-Ovest Liguria Genova Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Nicolas Zaghini (Dr.) Links Contact the organisation Opens in new window Total cost No data DANDO WEISS & COLUCCI LIMITED United Kingdom EU contribution € 338 566,46 Address LOWER BRISTOL ROAD MINERVA HOUSE BA2 9ER BATH See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jeffrey Dando (Mr.) Links Contact the organisation Opens in new window Total cost No data INTERCYTEX LTD United Kingdom EU contribution € 70 418,18 Address CREWE ROAD INNOVATION HOUSE M23 9QR MANCHESTER See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Richard Moulson (Mr.) Links Contact the organisation Opens in new window Total cost No data KUROS BIOSURGERY AG Switzerland EU contribution € 364 590,15 Address TECHNOPARKSTRASSE 1 8005 ZURICH See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Didier Cowling (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MILTENYI BIOTEC GMBH Germany EU contribution € 203 889,42 Address FRIEDRICH EBERT STRASSE 68 51429 Bergish Gladbach See on map Region Nordrhein-Westfalen Köln Rheinisch-Bergischer Kreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael Apel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BAXALTA INNOVATIONS GMBH Austria EU contribution € 34 800,00 Address INDUSTRIESTRASSE 67 1221 Wien See on map Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Johannes Regenbogen (Dr.) Links Contact the organisation Opens in new window Total cost No data SMITH & NEPHEW UK LIMITED United Kingdom EU contribution € 8 088,60 Address ADAM STREET 15 WC2N 6LA LONDON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rob Yates (Mr.) Links Contact the organisation Opens in new window Total cost No data BAYER INNOVATION GMBH Germany EU contribution € 1 731,14 Address MEROWINGER PLATZ 1 40225 DUSSELDORF See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Burkhard Fugmann (Dr.) Links Contact the organisation Opens in new window Total cost No data FONDAZIONE MULTIMEDICA ONLUS Italy EU contribution € 259 494,20 Address VIA FANTOLI 16/15 20138 MILANO See on map Activity type Research Organisations Administrative Contact Daniela Sperti (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR Participation ended Italy EU contribution € 116 762,96 Address Via Olgettina 60 20132 MILANO See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Mario Valsecchi (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA Italy EU contribution € 224 984,71 Address Piazzale Aldo Moro 5 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Higher or Secondary Education Establishments Administrative Contact Giancarlo Bertea (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON EU contribution € 128 063,30 Address GOWER STREET WC1E 6BT LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Greta Borg-Carbott (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISTITUTO NAZIONALE PER LA RICERCA SUL CANCRO Participation ended Italy EU contribution € 375 415,66 Address Largo Rosanna Benzi 10 16132 GENOVA See on map Activity type Research Organisations Administrative Contact Piera Castagnacci (Ms.) Links Contact the organisation Opens in new window Total cost No data