Objective This research project aims at the development, analysis and computer implementation of mathematical models of the cardiovascular system. Our goal is to describe and simulate the anatomic structure and the physiological response of the human cardiovascular system in healthy or diseased states. This demands to address many fundamental issues. Blood flow interacts both mechanically and chemically with the vessel walls and tissue, giving rise to complex fluid-structure interaction problems. The mathematical analysis of these problems is complicated and the related numerical analysis difficult. We propose to extend the recently achieved results on blood flow simulations by directing our analysis in several new directions. Our goal is to encompass aspects of metabolic regulation, micro-circulation, the electrical and mechanical activity of the heart, and their interactions. Modelling and optimisation of drugs delivery in clinical diseases will be addressed as well. This requires the understanding of transport, diffusion and reaction processes within the blood and organs of the body. The emphasis of this project will be put on mathematical modelling, numerical analysis, algorithm implementation, computational efficiency, validation and verification. Our purpose is to set up a mathematical simulation platform eventually leading to the improvement of vascular diseases diagnosis, setting up of surgical planning, and cure of inflammatory processes in the circulatory system. This platform might also help physicians to construct and evaluate combined anatomic/physiological models to predict the outcome of alternative treatment plans for individual patients. Fields of science medical and health sciencesclinical medicineangiologyvascular diseasesnatural sciencesmathematicspure mathematicsmathematical analysisnatural sciencesphysical sciencesclassical mechanicsfluid mechanicsnatural sciencesmathematicsapplied mathematicsnumerical analysisnatural sciencesmathematicsapplied mathematicsmathematical model Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-AG-PE1 - ERC Advanced Grant - Mathematical foundations Call for proposal ERC-2008-AdG See other projects for this call Funding Scheme ERC-AG - ERC Advanced Grant Coordinator ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE EU contribution € 1 293 720,40 Address Batiment ce 3316 station 1 1015 Lausanne Switzerland See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Caroline Vandevyver (Ms.) Principal investigator Alfio Quarteroni (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution € 1 293 720,40 Address Batiment ce 3316 station 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Administrative Contact Caroline Vandevyver (Ms.) Principal investigator Alfio Quarteroni (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data POLITECNICO DI MILANO Italy EU contribution € 517 271,60 Address Piazza leonardo da vinci 32 20133 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Administrative Contact Giuseppe Piampiano (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data