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Comparative epidemiology of genetic lineages of Trypanosoma cruzi

Objective

The focus of this multidisciplinary proposal is to elucidate the epidemiology of the genetic lineages of T. cruzi, for improved understanding and prevention of Chagas disease. The project will unite skills in genotyping, genomics, genetics and pathogenesis in Europe with considerable compatible skills in South America, and with key research in endemic areas that have distinct characteristics. The proposal is intended to be high impact in terms of both research progress and fostering of collaborative networks. Aim: Elucidate the epidemiology of the genetic lineages of T. cruzi, for improved understanding and prevention of Chagas disease. Technology development: 1. Develop further and apply MLST; PCR-RFLP and MLMT to the analysis of genetic populations of T. cruzi, 2. Sequence the unresolved genome of T. cruzi I, 3. Develop lineage specific diagnosis, 4. Develop an oligochromatography PCR-dipstick procedure for detection of T. cruzi. Molecular epidemiology: 5. Pilot studies of association between genetic lineage, clinical outcome, and prevalence of congenital infection, 6. Map the silvatic vector, silvatic mammal, human and ecological associations of the T. cruzi genotypes IId,e,b,a. 7. Compare lineage specific pathogenesis and transmissibility of congenital infection in a mouse model, and compare lineage susceptibility to drugs in vitro. Population genetics and phylogenetics: 8. Re-evaluate the population genetics and evolution of T. cruzi lineages. International cryobank and database: 9. Establish in South America an accessible, expanded, international cryobank for T. cruzi, 10. Establish a website and database for outputs of the project. The project encompasses the desirable characteristics prescribed by the call, in that they include: genomics/proteomics; effective, innovative relevance to disease, pathogenesis, drugs, interventions; an integrated multidisciplinarity, and capacity building, networking and training in endemic regions.

Field of science

  • /natural sciences/biological sciences/zoology/mammalogy
  • /natural sciences/biological sciences/genetics and heredity
  • /natural sciences/biological sciences/genetics and heredity/genome
  • /medical and health sciences/health sciences/epidemiology

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-SICA - Collaborative project for specific cooperation actions dedicated to international cooperation partner countries (SICA)

Coordinator

LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER
Address
Keppel Street
WC1E 7HT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 529 187
Administrative Contact
Penny Ireland (Ms.)

Participants (14)

PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE
Belgium
EU contribution
€ 307 800
Address
Nationalestraat 155
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jef Van Lint (Mr.)
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 212 400
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yves Carlier (Prof.)
INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT
France
EU contribution
€ 117 960
Address
Boulevard De Dunkerque 44 Cs 90009
13572 Marseille
Activity type
Research Organisations
Administrative Contact
Ariel Crozon (Ms.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 210 600
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Riitta Ljungstrom (Ms.)
UNIVERSITY OF EAST ANGLIA
United Kingdom
EU contribution
€ 200 160
Address
Earlham Road
NR4 7TJ Norwich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kevin Tyler (Dr.)
UNIVERSIDAD AUTONOMA DE MADRID
Spain
EU contribution
€ 200 160
Address
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Carmen Puerta (Ms.)
UNIVERSIDAD MAYOR DE SAN SIMON
Bolivia
EU contribution
€ 197 400
Address
Avenida Ballivian Esquina Reza 591
N/A Cochabamba
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Faustino Torrico (Dr.)
UNIVERSIDAD CENTRAL DE VENEZUELA
Venezuela
EU contribution
€ 208 440
Address
Cent Com Los Chaguaramos 6/10
1040 Caracas
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Hernan Jose Carrasco (Dr.)
UNIVERSIDAD NACIONAL DE SALTA
Argentina
EU contribution
€ 178 800
Address
Av Bolivia 5150
4400 Salta
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Raul Alberto Becchio (Dr.)
FUNDACAO OSWALDO CRUZ
Brazil
EU contribution
€ 146 400
Address
Avenida Brasil 4365
21040 900 Rio De Janeiro
Activity type
Research Organisations
Administrative Contact
Jansen Ana Maria (Dr.)
UNIVERSIDADE FEDERAL DE GOIAS
Brazil
EU contribution
€ 72 000
Address
Campus Samambaia
74001 970 Goiania
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alejandio Luquetti (Dr.)
UNIVERSIDAD DE LOS ANDES FUNDACION
Colombia
EU contribution
€ 90 000
Address
Carrera 1 18A-10
- Bogota Dc
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Luz Stella Moncaleano (Ms.)
UNIVERSIDAD DE CHILE
Chile
EU contribution
€ 56 400
Address
Av. Libertador Bernardo O'higgins 1058
10 Santiago
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aldo Solari (Prof.)
PONTIFICIA UNIVERSIDAD CATOLICA DEL ECUADOR
Ecuador
EU contribution
€ 148 800
Address
Av 12 De Octubre 1076 Y Patria
17012184 Quito
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mario Grijalva (Dr.)