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NOTCH SIGNALING IN DEVELOPMENT AND PATHOLOGY

NOTCH SIGNALING IN DEVELOPMENT AND PATHOLOGY

Objective

Eight partners from six different EU countries will converge in NotchIT, a multi-site ITN aimed to increase the knowledge of cellular and molecular mechanisms by which Notch signaling regulates the development and pathology of different tissues. Notch signaling plays a key role in cell-fate determination and differentiation of various cell types and aberrant Notch signaling is associated with pathogenesis of different human diseases, including cancer. NotchIT integrates the research and training activities of the eight different partners, who are all leaders in Notch signaling and related fields, to specifically address three strategic initiatives, which are central to European science and health economy: - the core Notch signaling mechanism with the purpose of constructing a state-of-the-art molecular tool box for Notch signaling and to disseminate this knowledge and reagents at a pan-European level. - the role of Notch signaling in the differentiation and pathology of various cell types with the purpose of using Notch signaling to improve our means to steer stem cell differentiation and to correct aberrant Notch signaling in pathologies. - how Notch signaling can be exogenously controlled through pharmacological approaches, in order to break new ground and to ultimately design new diagnostic and therapeutic protocols. The training component in NotchIT is deeply integrated with the research programme. The partners in NotchIT possess a wide range of expertise and work in operationally diverse environments: Hospitals, Universities, Research Institutes and Industry. This broad knowledge-base, combined with an integrated set of courses, workshops, meetings and cross-laboratory visits, provides an excellent training opportunity for early stage and experienced scientists in the center, and will prepare them for high level positions in academia and industry.

Coordinator

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Address

Piazzale Aldo Moro 5
00185 Roma

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 716 306,80

Administrative Contact

Giancarlo Bertea (Mr.)

Participants (9)

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THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 510 686

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 446 285,40

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

EU Contribution

€ 444 347,70

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 401 953,19

INSTITUT PASTEUR

France

EU Contribution

€ 190 763,10

NEWRON SWEDEN AB

Sweden

CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)

Spain

EU Contribution

€ 419 648,90

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

ACTAR AB

Sweden

EU Contribution

€ 330 008,91

Project information

Grant agreement ID: 215761

Status

Closed project

  • Start date

    1 January 2009

  • End date

    31 December 2012

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 3 460 000

  • EU contribution

    € 3 460 000

Coordinated by:

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Italy