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Carbohydrate Multivalent Systems as tools to study Pathogen interaction with DC-SIGN

Carbohydrate Multivalent Systems as tools to study Pathogen interaction with DC-SIGN

Objective

The importance of glycosciences in the development of biology and medicine and the central role played by chemistry in this process have recently been pointed out by ESF. However, it appears that exposure of young scientists in their training phase to the chemical biology of carbohydrates is still lacking. This multidisciplinary project intends to approach the design and synthesis of carbohydrate multivalent systems to be used as tools to study the interaction between carbohydrates and DC-SIGN (Dendritic Cell-Specific ICAM-3 Grabbing Non-integrin), a C-type lectin implicated in the recognition of pathogens and in some of the earliest stages of the infection process. Targeting pathogens at the earliest stages of infection, before cell penetration, is of crucial importance because it can result in a significant decrease of pathogen titre in the organism and therefore will facilitate the efficiency of current therapies. The role that DC-SIGN plays in the immune response through the interaction and recognition of pathogens leads to a very complex pathway of signalling cascade that could be modulated using these carbohydrate multivalent systems as effectors. Thus the studies we propose could provide the background for the design, selection and preparation of better antiviral drugs and could afford new insights to unravel the complex mechanisms of the immune system, thus opening a strategy to develop vaccines through the modulation of dendritic cells activity. To reach these goals, a highly interdisciplinary group of scientists (synthetic chemists, computational chemists, biochemists, immunologists, etc.) has been assembled, some of whom are already collaborating on the topic. The planned flow of information between laboratories and the network-wide training activities described in this proposal will create an unrivalled environment for training of young scientists in glycosciences.

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Address

Calle Serrano 117
28006 Madrid

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 512 344,76

Administrative Contact

Carlos Manuel Abad (Mr.)

Participants (12)

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UNIVERSITA DEGLI STUDI DI MILANO

Italy

EU Contribution

€ 408 247,38

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 213 280,08

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 391 758,39

"FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL UNIVERSITARIO ""DOCE DE OCTUBRE"""

Spain

EU Contribution

€ 201 062,39

INSTITUT PASTEUR

France

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 410 260,38

VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE

Czechia

EU Contribution

€ 175 940,59

VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

Netherlands

EU Contribution

€ 208 887,79

anterio consult & research GmbH

Germany

EU Contribution

€ 178 032,79

DC4U

Netherlands

EU Contribution

€ 177 625,80

UNIVERSITE JOSEPH FOURIER GRENOBLE 1

France

EU Contribution

€ 33 000

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 213 280,08

Project information

Grant agreement ID: 213592

Status

Closed project

  • Start date

    1 January 2009

  • End date

    31 December 2012

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 3 123 720,43

  • EU contribution

    € 3 123 720,43

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

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