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Early diagnosis, treatment and prevention of mood disorders targetting the activated inflammatory response system

Early diagnosis, treatment and prevention of mood disorders targetting the activated inflammatory response system

Objective

Partners come from 10 European countries to achieve two main objectives: A) The further exploration of 3 animal models (the OBX rat, GS rat and NOD mouse) characterized by an activated immune response system (IRS), an abnormal tryptophan catabolism and a depressive-like behaviour to study the pathogenesis of inflammation-related mood disorders and the efficacy/working mechanism of anti-inflammatory and tryptophan metabolism restoring drugs. B) The in-parallel study of mood disorder patients to validate two sets of already developed biomarker tests to identify patients and individuals at risk for a mood disorder and characterized by an activated IRS to be able to treat these patients/individuals with drugs counteracting the consequences of the activated IRS/disturbed catabolism of tryptophan. Five strategic approaches (broken down in 12 workpackages) are used: 1) Study of the animal models for depressive-like behavior and aberrancies in monocytes/ macrophages, the tryptophan metabolism and the microglia-astrocyte-neuron interaction. 2/3) The validation of a high-throughput biomarker mRNA blood monocyte signature test and a biomarker test to detect an abnormal tryptophan catabolism. 4) Correlation studies between the outcomes of these biomarker tests in patients to various clinical variables, a.o. gene polymorphisms and the brain scan. 5) The therapeutic targetting of the activated IRS/abnormal tryptophan catabolism using a PDE4 inhibitor, a COX-2 inhibitor and a KMO-inhibitor in the animal models and in a phase II intervention study in depressed patients. Novel approaches are the prospective assessment of patients/individuals to identify whether changes in the IRS have any prognostic value and that the program aims at a personalized treatment of patients on the basis of their activated IRS. We heavily rely in this on the study of the animal models, which allow us to test anti-inflammatory therapeutics and to know their mechanism of action at the brain.
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Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Address

Dr Molewaterplein 40
3015 Gd Rotterdam

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 641 782,40

Administrative Contact

Hemmo A. Drexhage (Prof.)

Participants (20)

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LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 1 408 500

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany

EU Contribution

€ 783 800

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 393 605,20

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Austria

EU Contribution

€ 528 400

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 583 000

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 544 000

Fondazione Centro San Raffaele

Italy

EU Contribution

€ 267 133

Foundation Biological Psychiatry

Bulgaria

EU Contribution

€ 483 500

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

Ireland

EU Contribution

€ 423 882

UNIVERSITY OF BRADFORD

United Kingdom

EU Contribution

€ 372 400

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 372 400

HUMANITAS MIRASOLE SPA

Italy

EU Contribution

€ 228 300

UPPSALA UNIVERSITET

Sweden

EU Contribution

€ 286 000

CROSSLINKS BV

Netherlands

EU Contribution

€ 372 500

ADVANCED PRACTICAL DIAGNOSTICS

Belgium

EU Contribution

€ 384 100

Affectis Phamaceuticals AG

Germany

EU Contribution

€ 316 835,60

NEWRON PHARMACEUTICALS SPA

Italy

EU Contribution

€ 97 700

UNIVERSITAETSKLINIKUM FREIBURG

Germany

EU Contribution

€ 372 400

UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Netherlands

EU Contribution

€ 123 394,80

Fondazione Centro San Raffaele

Italy

EU Contribution

€ 251 952

Project information

Grant agreement ID: 222963

Status

Closed project

  • Start date

    1 November 2008

  • End date

    30 April 2013

Funded under:

FP7-HEALTH

  • Overall budget:

    € 13 761 545,68

  • EU contribution

    € 10 235 585

Coordinated by:

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

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