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Early diagnosis, treatment and prevention of mood disorders targetting the activated inflammatory response system

Objective

Partners come from 10 European countries to achieve two main objectives: A) The further exploration of 3 animal models (the OBX rat, GS rat and NOD mouse) characterized by an activated immune response system (IRS), an abnormal tryptophan catabolism and a depressive-like behaviour to study the pathogenesis of inflammation-related mood disorders and the efficacy/working mechanism of anti-inflammatory and tryptophan metabolism restoring drugs. B) The in-parallel study of mood disorder patients to validate two sets of already developed biomarker tests to identify patients and individuals at risk for a mood disorder and characterized by an activated IRS to be able to treat these patients/individuals with drugs counteracting the consequences of the activated IRS/disturbed catabolism of tryptophan. Five strategic approaches (broken down in 12 workpackages) are used: 1) Study of the animal models for depressive-like behavior and aberrancies in monocytes/ macrophages, the tryptophan metabolism and the microglia-astrocyte-neuron interaction. 2/3) The validation of a high-throughput biomarker mRNA blood monocyte signature test and a biomarker test to detect an abnormal tryptophan catabolism. 4) Correlation studies between the outcomes of these biomarker tests in patients to various clinical variables, a.o. gene polymorphisms and the brain scan. 5) The therapeutic targetting of the activated IRS/abnormal tryptophan catabolism using a PDE4 inhibitor, a COX-2 inhibitor and a KMO-inhibitor in the animal models and in a phase II intervention study in depressed patients. Novel approaches are the prospective assessment of patients/individuals to identify whether changes in the IRS have any prognostic value and that the program aims at a personalized treatment of patients on the basis of their activated IRS. We heavily rely in this on the study of the animal models, which allow us to test anti-inflammatory therapeutics and to know their mechanism of action at the brain.

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 641 782,40
Administrative Contact
Hemmo A. Drexhage (Prof.)

Participants (20)

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 1 408 500
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Norbert Mueller (Prof.)
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
EU contribution
€ 783 800
Address
Schlossplatz 2
48149 Munster
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katharina Steinberg (Dr.)
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 393 605,20
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
J.J. Breeuwsma (Mr.)
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
EU contribution
€ 528 400
Address
Christoph Probst Platz 1
6020 Innsbruck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Thomas Hegenauer (Mr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 583 000
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Vereeken (Ms.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 544 000
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Silke Blohm (Ms.)
FONDAZIONE CENTRO SAN RAFFAELE DEL MONTE TABOR
Italy
EU contribution
€ 267 133
Address
Via Olgettina 60
20132 Milano
Activity type
Research Organisations
Administrative Contact
Maria Rosa Pedrazzi (Dr.)
Foundation Biological Psychiatry
Bulgaria
EU contribution
€ 483 500
Address
Svilenitsa Str 8
1463 Sofia
Activity type
Research Organisations
Administrative Contact
Olya Mikova-Demireva (Dr.)
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
EU contribution
€ 423 882
Address
College Green
2 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Deirdre Savage (Ms.)
UNIVERSITY OF BRADFORD
United Kingdom
EU contribution
€ 372 400
Address
Richmond Road
BD7 1DP Bradford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sheila Frye (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 372 400
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Evelyne Lasfargues (Ms.)
HUMANITAS MIRASOLE SPA
Italy
EU contribution
€ 228 300
Address
Via Manzoni 56
20100 Rozzano (Mi)
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marina Lancellotti (Dr.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 286 000
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Pirkko Boox (Ms.)
CROSSLINKS BV

Participation ended

Netherlands
EU contribution
€ 372 500
Address
Statenlaan 71
3051 HM Rotterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ronald Nanninga (Mr.)
ADVANCED PRACTICAL DIAGNOSTICS
Belgium
EU contribution
€ 384 100
Address
Raadsherenstraat 3
2300 Turnhout
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Aye Mu Myint (Dr.)
Affectis Phamaceuticals AG
Germany
EU contribution
€ 316 835,60
Address
Fraunhoferstrasse 13
82152 Martinsried
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Herbert Stadler (Dr.)
NEWRON PHARMACEUTICALS SPA
Italy
EU contribution
€ 97 700
Address
Via Ludovico Ariosto 21
20091 Bresso
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patricia Salvati (Dr.)
UNIVERSITAETSKLINIKUM FREIBURG
Germany
EU contribution
€ 372 400
Address
Hugstetter Strasse 49
79106 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jürgen Dreyer (Mr.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 123 394,80
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Manon Hillegers (Dr.)
FONDAZIONE CENTRO SAN RAFFAELE
Italy
EU contribution
€ 251 952
Address
Via Olgettina 60
20132 Milano
Activity type
Research Organisations
Administrative Contact
Maria Rosa Pedrazzi Pedrazzi (Dr.)