Skip to main content

Early and late health risks to normal/healthy tissues from the use of existing and emerging techniques for radiation therapy

Objective

Curative cancer treatment with radiation seeks to optimise the magnitude of the radiation dose to the treatment volume while restricting the dose to normal healthy tissue. With an increasing population of surviving cancer patients treated with radiation therapy, the harmful effects of the radiation to normal tissue are becoming more evident. The ALLEGRO project will address the many aspects of normal healthy tissue damage that are not yet well understood in both conventional treatment techniques and emerging techniques (protons, heavy ions). The project will include measurement of radiation doses outside the treatment volume and investigation of the accuracy of methods of dose calculation in this region. The extensive existing databases of radiation treatments and outcomes will be used to investigate models of normal tissue damage and second primary cancer. The measurements and data analysis will be supported by theoretical modelling and surveys to develop the link between radiobiological mechanisms and empirical normal tissue complication (NTCP) models, and to extend conventional models to apply to the emerging techniques. The project is restricted to two years, so there will be a limit to the amount of new research possible. Therefore an essential part of the project will be to engage a forum of experts to redefine the current knowledge on normal tissue damage following radiotherapy, identify gaps in the knowledge and make recommendations for future research, data collection, and technological developments. The final report will consist of a series of focused documents directed to clinicians (for the application of normal tissue risks in treatment optimisation), equipment manufacturers (recommendations on safety design), and the research community (summary of knowledge and recommendations on data collection and project proposals).

Field of science

  • /natural sciences/computer and information sciences/databases
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /natural sciences/computer and information sciences/data science/data analysis

Call for proposal

FP7-Fission-2008
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITA DEGLI STUDI DI PAVIA
Address
Strada Nuova 65
27100 Pavia
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 478 440

Participants (12)

AARHUS UNIVERSITETSHOSPITAL
Denmark
EU contribution
€ 130 000
Address
Palle Juul-jensens Boulevard 99
8200 Aarhus
Activity type
Research Organisations
CHALMERS TEKNISKA HOEGSKOLA AB
Sweden
EU contribution
€ 205 500
Address
-
41296 Goeteborg
Activity type
Higher or Secondary Education Establishments
EUROPEAN SOCIETY FOR RADIOTHERAPY AND ONCOLOGY
Belgium
EU contribution
€ 145 800
Address
Rue Martin V 40
1200 Bruxelles
Activity type
Other
GSI HELMHOLTZZENTRUM FUER SCHWERIONENFORSCHUNG GMBH
Germany
EU contribution
€ 350 000
Address
Planckstrasse 1
64291 Darmstadt
Activity type
Other
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy
EU contribution
€ 88 800
Address
Via Filodrammatici 10
20121 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 260 100
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 32 700
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
East & North Hertfordshire National Health Service Trust
United Kingdom
EU contribution
€ 65 250
Address
Lister Hospital Coreys Mill Lane
SG1 4AB
Activity type
Research Organisations
PAUL SCHERRER INSTITUT
Switzerland
EU contribution
€ 186 000
Address
Forschungstrasse 111
5232 Villigen Psi
Activity type
Research Organisations
TECHNISCHE UNIVERSITAET DRESDEN
Germany
EU contribution
€ 313 800
Address
Helmholtzstrasse 10
01069 Dresden
Activity type
Higher or Secondary Education Establishments
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
EU contribution
€ 243 960
Address
Hanzeplein 1
9713 GZ Groningen
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET ULM
Germany
EU contribution
€ 99 000
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments