Objective This project concerns the first large-scale application of the full range of –omics technologies in a population study aiming at a) the discovery and validation of novel biomarkers predictive of increased risks of a number of chronic diseases, b) the exploration of the association of such biomarkers with environmental exposures, including high-priority pollutants and emerging exposures, and c) the discovery and validation of biomarkers of exposure to the above and other high-priority environmental exposures. The project will utilise three existing prospective cohorts. Cancer-related -omics biomarkers will be developed using a case-control study nested within 2 cohorts which contain biosamples collected prior to disease diagnosis, exposure and followup health information. Biomarkers will be compared in 600 breast cancer cases, 300 NHL cases and equal numbers of matched controls, to evaluate their risk predictivity. Biomarkers of chronic diseases which establish themselves in early childhood but persist into adult life will be evaluated using a mother-child cohort. Biosamples collected from 600 children at birth and at ages 2 and 4 years will be analysed and results compared with clinical indices obtained at age 4. Thanks to the availability of repeat samples, collected over a wide range of time intervals, the intra-individual variation of biomarkers and their relationship with disease progression will be evaluated. Biomarker search will utilize state-of-the-art metabonomics, epigenomics, proteomics and transcriptomics, in combination with advanced bioinformatics and systems biology tools. It will also include technical validation of -omics technology’s utilisation with biobank samples. Exposure assessment will utilize exposure biomarkers, questionnaires, modelling and GIS technology. Additional data on exposure, biomarkers (including SNP data) and health indices, available through other projects, will be utilised, thus generating substantial added value. Fields of science medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesearth and related environmental sciencesphysical geographycartographygeographic information systemsmedical and health sciencesclinical medicineoncologybreast cancernatural sciencesbiological sciencesgeneticsepigenetics Keywords allergy breast cancer epigenetics immune disease lymphoma metabonomics molecular epidemiology neurological disease proteomics transcriptomics Programme(s) FP7-ENVIRONMENT - Specific Programme "Cooperation": Environment (including Climate Change) Topic(s) ENV.2008.1.2.1.4. - New, improved and validated biomarkers to investigate long-term health impacts of exposure to environmental pollutants Call for proposal FP7-ENV-2008-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator ETHNIKO IDRYMA EREVNON EU contribution € 474 174,40 Address VAS KONSTANTINOU 48 11635 Athina Greece See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Administrative Contact Soterios Kyrtopoulos (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITEIT MAASTRICHT Netherlands EU contribution € 643 091,00 Address MINDERBROEDERSBERG 4 6200 MD Maastricht See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Higher or Secondary Education Establishments Administrative Contact René Reijnders (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom EU contribution € 437 001,20 Address SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Michael Robinson (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UMEA UNIVERSITET Sweden EU contribution € 324 900,00 Address UNIVERSITETOMRADET 901 87 Umea See on map Region Norra Sverige Övre Norrland Västerbottens län Activity type Higher or Secondary Education Establishments Administrative Contact Ellinor ädelroth (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISTITUTO PER LO STUDIO E LA PREVENZIONE E LA RETE ONCOLOGICA Italy EU contribution € 235 200,00 Address VIA COSIMO IL VECCHIO 2 50139 Firenze See on map Region Centro (IT) Toscana Firenze Activity type Other Administrative Contact Elena Lacquaniti (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PANEPISTIMIO KRITIS Greece EU contribution € 260 000,40 Address UNIVERSITY CAMPUS GALLOS 74100 Rethimno See on map Region Νησιά Αιγαίου Κρήτη Ρέθυμνο Activity type Higher or Secondary Education Establishments Administrative Contact Eva Michelidaki (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT UTRECHT Netherlands EU contribution € 417 375,00 Address HEIDELBERGLAAN 8 3584 CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Monique Van Der Hoek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISTITUTO SUPERIORE DI SANITA Italy EU contribution € 50 000,40 Address Viale Regina Elena 299 00161 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Rosa Maria Martoccia (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TERVEYDEN JA HYVINVOINNIN LAITOS Finland EU contribution € 334 257,60 Address MANNERHEIMINTIE 166 00271 Helsinki See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Research Organisations Administrative Contact Jaakko Penttinen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF LEEDS United Kingdom EU contribution € 204 000,00 Address WOODHOUSE LANE LS2 9JT Leeds See on map Region Yorkshire and the Humber West Yorkshire Leeds Activity type Higher or Secondary Education Establishments Administrative Contact Kathy Brownridge (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX IV Laboratory, Lund University Sweden EU contribution € 120 000,00 Address Paradisgatan 5c 22100 LUND See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Administrative Contact Bo Jönsson (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NATIONAL TAIWAN UNIVERSITY Taiwan EU contribution No data Address ROOSEVELT ROAD 1 10617 Taipei See on map Activity type Higher or Secondary Education Establishments Administrative Contact Fang-Yu Hu (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
