CORDIS
EU research results

CORDIS

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Integration of Novel Nanoparticle based Technology for Therapeutics and Diagnosis of different types of Cancer

Project information

Grant agreement ID: 213631

Status

Closed project

  • Start date

    1 September 2008

  • End date

    31 August 2012

Funded under:

FP7-NMP

  • Overall budget:

    € 11 556 307,55

  • EU contribution

    € 8 408 483

Coordinated by:

FUNDACION GAIKER

Spain

Objective

The breakthrough objective of NANOTHER is to develop & characterise a novel nanoparticle system that will be used as a therapeutic agent or diagnosis tool for breast cancer, colorectal cancer & bone metastasis. Theranostics, the development of nanoparticles with both functionalities, will also be carried out using the hyperthermic effect to kill tumour cells or to release the selected drug . The nanoparticles used in NANOTHER will be selected based on previous studies. Therefore, only polymeric micelles core-shell nanoparticles and magnetic nanoparticles will be included in the study. The nanoparticles will be functionalised by attaching targeting molecules, depending on the type of cancer to be treated or diagnosed. Labels for diagnosis will include fluorescent or contrast phase probes, which will later be imaged and analysed with the appropriate equipment optimised during the project. Therapeutic agents will be loaded on to the nanoparticle, including drugs like doxorubicin, and new marine pharmacological compounds already in clinical trials. One of the most innovative aspects of this proposal is the use of siRNA as the therapeutic agent. The use of magnetic nanoparticles as a theranostic mechanism is also an innovative aspect of the proposal, as these nanoparticles can be activated to kill tumour cells detected depending on a positive or negative diagnostic. The project has been structured in seven different sub-projects including aspects like toxicology, biocompatibility of the nanodevices, and also efficacy and biodistribution of the system. In vitro (cellular models) & in vivo assays (small animals; mice) will be used for the study of diagnosis & therapy. The latter will be kept to the minimum necessary to study the efficiency & biodistribution and always taking into account the three Rs & national / EU norms. The NANOTHER consortium includes 18 top-level partners from 8 EU countries as the critical mass required to achieve ambitious project objectives.

Coordinator

FUNDACION GAIKER

Address

Parque Tecnologico De Vizcaya, Edificio 202
48170 Zamudio

Spain

Activity type

Research Organisations

EU Contribution

€ 1 187 724,90

Administrative Contact

Oscar Salas (Mr.)

Participants (18)

TEL AVIV UNIVERSITY

Israel

EU Contribution

€ 810 170,25

PHARMAMAR, S.A.

Spain

EU Contribution

€ 332 380,50

FEYECON DEVELOPMENT & IMPLEMENTATION BV

Netherlands

EU Contribution

€ 121 800

CONSORZIO INTERUNIVERSITARIO NAZIONALE PER LA SCIENZA E TECNOLOGIA DEI MATERIALI

Italy

EU Contribution

€ 951 284

AHAVA DEAD SEA LABORATORIES LTD

Israel

EU Contribution

€ 256 492,50

ASOCIACION CENTRO DE TECNOLOGIAS DE INTERACCION VISUAL Y COMUNICACIONES-VICOMTECH

Spain

EU Contribution

€ 347 662,50

COLOROBBIA ITALIA SPA

Italy

EU Contribution

€ 505 700

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS

Spain

EU Contribution

€ 288 315

DOMINION PHARMAKINE S.L.

Spain

EU Contribution

€ 158 295,05

JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION

Belgium

EU Contribution

€ 405 051

HAMELN RDS AS

Slovakia

EU Contribution

€ 275 734,43

INSTITUT POLYTECHNIQUE DE BORDEAUX

France

EU Contribution

€ 952 208,72

TECHNOLOGIKO EKPAIDEFTIKO IDRYMA ATHINAS

Greece

EU Contribution

€ 342 840

UNIVERSITE VICTOR SEGALEN BORDEAUX II

France

EU Contribution

€ 326 016

NuovoProbe Ltd

United Kingdom

EU Contribution

€ 278 692

ARGUS CHEMICAL SRL

Italy

EU Contribution

€ 120 848,15

AYMING

France

EU Contribution

€ 343 880

ACONDICIONAMIENTO TARRASENSE ASSOCIACION

Spain

EU Contribution

€ 403 388

Project information

Grant agreement ID: 213631

Status

Closed project

  • Start date

    1 September 2008

  • End date

    31 August 2012

Funded under:

FP7-NMP

  • Overall budget:

    € 11 556 307,55

  • EU contribution

    € 8 408 483

Coordinated by:

FUNDACION GAIKER

Spain

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