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Image-controlled Ultrasound-induced Drug Delivery

Objective

The demographic changes in Europe towards an aging society will coincide with increasing morbidity of the population. European citizens need improved access to state-of-the-art medical care especially in oncology and cardiology, while keeping expenditures on healthcare affordable. New therapeutic options such as externally triggered local drug release at the diseased area hold promise to solve urgent medical needs: improved treatment with reduced side effects, fewer burdens to the patient and faster recovery after intervention. Nanomedicine, the application of nanomaterials and nanotechnology to healthcare, will enable breakthroughs in clinical practice. SONODRUGS addresses clinical needs by developing novel drug delivery technologies for localised treatment of cardiovascular disease and cancer. SONODRUGS develops drug delivery concepts where drug release can be triggered by focused ultrasound induced pressure or temperature stimuli within the diseased tissue. New drug loaded nanocarriers will be designed for tailored drug delivery systems that respond to either of the two stimuli. Medical imaging, i.e. magnetic resonance imaging and ultrasound imaging, will be used to guide, follow and quantify the drug delivery process. Therapy efficacy using different drug delivery systems will be assessed in vitro and subsequently in preclinical studies. Starting form research on a broad range of materials and drugs, two nanocarriers will be finally selected, optimized and produced on a pilot scale in combination with image-guided delivery tools and methods. SONODRUGS binds expertise in materials research (Philips, TUE, GhentRGN, HBBG); material production (Nanobiotix, Lipoid); clinical knowledge in oncology (UTours, HBBG) and cardiology (UKB); in vitro and preclinical validation (UTours, ErasmusMC, UKB); research on imaging techniques (UCY, Philips, IMF); pharmacokinetics, toxicology and biodistribution (ULSOP, IPT).

Field of science

  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging
  • /natural sciences/physical sciences/acoustics/ultrasound
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmacokinetics
  • /engineering and technology/nanotechnology
  • /medical and health sciences/medical biotechnology/nanomedicine
  • /medical and health sciences/clinical medicine/cardiology
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology
  • /medical and health sciences/clinical medicine/radiology/medical imaging
  • /medical and health sciences/basic medicine/toxicology
  • /engineering and technology/nanotechnology/nano-materials

Call for proposal

FP7-NMP-2007-LARGE-1
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

PHILIPS ELECTRONICS NEDERLAND BV
Address
High Tech Campus 52
5656 AG Eindhoven
Netherlands
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 2 669 228,40
Administrative Contact
Patrick Keur (Mr.)

Participants (17)

PHILIPS TECHNOLOGIE GMBH
Germany
EU contribution
€ 339 503
Address
Luebeckertordamm 5
20099 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Keur (Mr.)
LIPOID GMBH
Germany
EU contribution
€ 115 200
Address
Frigenstrasse 4
67065 Ludwigshafen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Katharina Sauter (Dr.)
NANOBIOTIX SA
France
EU contribution
€ 738 000
Address
Rue De Wattignies, Batiment B 60
75012 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kader Boussaha (Mr.)
UNIVERSITY OF CYPRUS
Cyprus
EU contribution
€ 404 910
Address
Kallipoleos Street 75
1678 Nicosia
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Antreas Christofides (Mr.)
UNIVERSITEIT GENT
Belgium
EU contribution
€ 839 952
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nathalie Vandepitte (Ms.)
HELSINGIN YLIOPISTO

Participation ended

Finland
EU contribution
€ 383 608
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katariina Vainio-Mattila (Ms.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kostas Kostarelos (Prof.)
TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands
EU contribution
€ 887 840
Address
Groene Loper 3
5612 AE Eindhoven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Rob Debeij (Mr.)
UNIVERSITE DE TOURS
France
EU contribution
€ 472 353,60
Address
Rue Du Plat D Etain 60
37020 Tours
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marie Bechtet (Ms.)
UNIVERSITE VICTOR SEGALEN BORDEAUX II

Participation ended

France
EU contribution
€ 426 778
Address
Rue Leo Saignat 146
33076 Bordeaux Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Chrit Moonen (Dr.)
Philips Oy
Finland
EU contribution
€ 239 000
Address
Ayritie 4
01511 Vantaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Panu Kauppila (Mr.)
UNIVERSITA DEGLI STUDI DI UDINE

Participation ended

Italy
EU contribution
€ 38 115
Address
Via Palladio 8
33100 Udine
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mario Furnalut (Prof.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 681 092
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nico De Jong (Prof.)
WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER
Germany
EU contribution
€ 790 911
Address
Schlossplatz 2
48149 Munster
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karl-Heinz Runde (Mr.)
AALTO KORKEAKOULUSAATIO SR
Finland
EU contribution
€ 307 416
Address
Otakaari 1
02150 Espoo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paavo Kinnunen (Prof.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 476 066
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Marieke Krispijn (Ms.)
THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON

Participation ended

United Kingdom
EU contribution
€ 973 927
Address
Brunswick Square 29-39
WC1N 1AX London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kostas Kostarelos (Prof.)