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Magnetic Scaffolds for in vivo Tissue Engineering

Magnetic Scaffolds for in vivo Tissue Engineering

Objective

The main driving idea of the project is the creation of conceptually new type of scaffolds able to be manipulated in situ by means of magnetic forces. This approach is expected to generate scaffolds with such characteristics as multiple use and possibly multipurpose delivery in order to repair large bone defects and ostheocondral lesions in the articular surface of the skeletal system. The major limitations of the scaffolds for bone and cartilage regeneration nowadays available in the market are related to the difficulties in controlling cell differentiation and angiogenesis processes and to obtain stable scaffold implantation in the pathological site. . . Several attempts have been performed over the last years in order to provide scaffolds for tissue engineering, but nowadays there is no way to grant that tissue regeneration take place in the pathological site. The provision in vivo of the scaffold with staminal cells or /and growth factors in order to drive the tissue differentiation process and parallel angiogenesis represents nowadays one of most challenging requests [Ref. Nanomedicine roadmap]. The Consortium aims to elaborate, investigate and fabricate new kind of scaffolds – magnetic scaffolds (MagS) - characterized by strongly enhanced control and efficiency of the tissue regeneration and angiogenic processes. The magnetic moment of the scaffolds enables them with a fascinating possibility of being continuously controlled and reloaded from external supervising center with all needed scaffold materials and various active factors (AF). Such a magnetic scaffold can be imagined as a fixed “station” that offers a long-living assistance to the tissue engineering, providing thus a unique possibility to adjust the scaffold activity to the personal needs of the patient.
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Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE

Address

Piazzale Aldo Moro 7
00185 Roma

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 575 606

Administrative Contact

Valentin Dediu (Dr.)

Participants (19)

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ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA

Italy

EU Contribution

€ 1 075 600

FIN-CERAMICA FAENZA SPA

Italy

EU Contribution

€ 400 137

RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

Germany

EU Contribution

€ 380 250

UNIVERSITAT POLITECNICA DE VALENCIA

Spain

EU Contribution

€ 482 963

BIO-VAC ESPANA SA

Spain

EU Contribution

€ 138 600

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Spain

EU Contribution

€ 400 500

HELMHOLTZ-ZENTRUM DRESDEN-ROSSENDORF EV

Germany

EU Contribution

€ 348 594

EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT

Switzerland

EU Contribution

€ 390 040

THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 448 021

SVEUCILISTE U ZAGREBU MEDICINSKI FAKULTET

Croatia

EU Contribution

€ 210 400

UNIVERSITATSSPITAL BASEL

Switzerland

EU Contribution

€ 329 792

INVENT SRL

Italy

EU Contribution

€ 356 000

I+ SRL

Italy

EU Contribution

€ 270 000

BIODEVICE SYSTEMS SRO

Czechia

EU Contribution

€ 174 563

BELARUSSIAN STATE MEDICAL UNIVERSITY

Belarus

EU Contribution

€ 285 513

EXPLORA SRL

Italy

EU Contribution

€ 336 000

AvantiCell Science Ltd

United Kingdom

EU Contribution

€ 245 401

Central Institute of Orthopedics and Traumatology of Russia

Russia

EU Contribution

€ 100 000

UNIVERSITY OF BRIGHTON

United Kingdom

EU Contribution

€ 330 111

Project information

Grant agreement ID: 214685

Status

Closed project

  • Start date

    1 December 2008

  • End date

    30 November 2012

Funded under:

FP7-NMP

  • Overall budget:

    € 11 085 124

  • EU contribution

    € 8 278 091

Coordinated by:

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

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