CORDIS
EU research results

CORDIS

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Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease

Project information

Grant agreement ID: 222915

Status

Closed project

  • Start date

    1 January 2009

  • End date

    30 June 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 432 418,46

  • EU contribution

    € 2 695 402

Coordinated by:

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

Objective

The main purpose of the EVINCI-study is to test the impact of combined “anatomo-functional” non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumoral characterization, including novel circulating markers of cardiovascular risk. They will be admitted to a non-invasive cardiac evaluation, consisting of “anatomic” imaging, by multislice computerized tomography, combined with “functional” tests among radionuclide, magnetic resonance and ultrasound imaging. Heart catheterization will be performed to validate non-invasive diagnosis and follow-up to assess outcome. The diagnostic accuracy of combined non-invasive “anatomo-functional” imaging will be tested against reference methods for diagnosing epicardial coronary lesions (coronary angiography), vessel wall atherosclerosis (intracoronary ultrasound) and impaired coronary flow reserve (intracoronary doppler/pressure wire). The individual profiles from “anatomo-functional” cardiac imaging and “clinical-biohumoral” data will be combined and tested against outcome. A cost-benefit analysis (including an estimate of procedural/radiological risks) of the new diagnostic work-up will also be performed. A relevant part of the EVINCI-study will be dedicated to the development, in cooperation with the industry, of an advanced informatics’ platform able to synthetically present to the end-user (patients, physicians, etc.) the integrated cardiological diagnostic profile of the individual patient as resulting from clinical-biohumoral and multi-imaging assessment. Overall results will be disseminated in cooperation with the European Society of Cardiology (ESC) and will guide the work of a dedicated ESC Commission which will release specific European Recommendations.

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE

Address

Piazzale Aldo Moro 7
00185 Roma

Italy

Activity type

Research Organisations

EU Contribution

€ 632 071

Administrative Contact

Marco Borbotti (Mr.)

Participants (21)

TURUN YLIOPISTO

Finland

EU Contribution

€ 450 023,09

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 92 706

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 199 115,02

TECHNISCHE UNIVERSITAET MUENCHEN

Germany

FUNDACIO PRIVADA INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU

Spain

EU Contribution

€ 12 883,59

INSTYTUT KARDIOLOGII IM. PRYMASA TYSIACLECIA STEFANA KARDYNALA WYSZYNSKIEGO

Poland

EU Contribution

€ 89 980,81

ROYAL BROMPTON AND HAREFIELD NATIONAL HEALTH SERVICE TRUST

United Kingdom

EU Contribution

€ 95 272,12

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

France

EU Contribution

€ 84 513,16

UNIVERSITA DEGLI STUDI DI GENOVA

Italy

EU Contribution

€ 112 821,36

SERVICIO MADRILENO DE SALUD

Spain

EU Contribution

€ 107 893,24

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II

Italy

EU Contribution

€ 45 032,36

INSTITUT CATALA DE LA SALUT

Spain

EU Contribution

€ 56 265,54

SOCIETE EUROPEENNE DE CARDIOLOGIE

France

EU Contribution

€ 28 180

INFORSENSE LIMITED

United Kingdom

EU Contribution

€ 46 740,90

CFc srl

Italy

EU Contribution

€ 79 661,10

FONDAZIONE TOSCANA GABRIELE MONASTERIO PER LA RICERCA MEDICA E DI SANITA PUBBLICA

Italy

EU Contribution

€ 233 031,84

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

Germany

EU Contribution

€ 98 962,99

QUEEN MARY UNIVERSITY OF LONDON

United Kingdom

EU Contribution

€ 120 247,88

AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI

Italy

EU Contribution

€ 40 000

Azienda U.S.L. N. 12 di Viareggio

Italy

EU Contribution

€ 30 000

KLINIKEN DES LANDKREISES GOPPINGEN GGMBH

Germany

EU Contribution

€ 40 000

Project information

Grant agreement ID: 222915

Status

Closed project

  • Start date

    1 January 2009

  • End date

    30 June 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 432 418,46

  • EU contribution

    € 2 695 402

Coordinated by:

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

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