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Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease

Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease

Objective

The main purpose of the EVINCI-study is to test the impact of combined “anatomo-functional” non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumoral characterization, including novel circulating markers of cardiovascular risk. They will be admitted to a non-invasive cardiac evaluation, consisting of “anatomic” imaging, by multislice computerized tomography, combined with “functional” tests among radionuclide, magnetic resonance and ultrasound imaging. Heart catheterization will be performed to validate non-invasive diagnosis and follow-up to assess outcome. The diagnostic accuracy of combined non-invasive “anatomo-functional” imaging will be tested against reference methods for diagnosing epicardial coronary lesions (coronary angiography), vessel wall atherosclerosis (intracoronary ultrasound) and impaired coronary flow reserve (intracoronary doppler/pressure wire). The individual profiles from “anatomo-functional” cardiac imaging and “clinical-biohumoral” data will be combined and tested against outcome. A cost-benefit analysis (including an estimate of procedural/radiological risks) of the new diagnostic work-up will also be performed. A relevant part of the EVINCI-study will be dedicated to the development, in cooperation with the industry, of an advanced informatics’ platform able to synthetically present to the end-user (patients, physicians, etc.) the integrated cardiological diagnostic profile of the individual patient as resulting from clinical-biohumoral and multi-imaging assessment. Overall results will be disseminated in cooperation with the European Society of Cardiology (ESC) and will guide the work of a dedicated ESC Commission which will release specific European Recommendations.
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Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE

Address

Piazzale Aldo Moro 7
00185 Roma

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 632 071

Administrative Contact

Marco Borbotti (Mr.)

Participants (21)

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TURUN YLIOPISTO

Finland

EU Contribution

€ 450 023,09

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 92 706

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 199 115,02

TECHNISCHE UNIVERSITAET MUENCHEN

Germany

FUNDACIO PRIVADA INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU

Spain

EU Contribution

€ 12 883,59

INSTYTUT KARDIOLOGII IM. PRYMASA TYSIACLECIA STEFANA KARDYNALA WYSZYNSKIEGO

Poland

EU Contribution

€ 89 980,81

ROYAL BROMPTON AND HAREFIELD NATIONAL HEALTH SERVICE TRUST

United Kingdom

EU Contribution

€ 95 272,12

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

France

EU Contribution

€ 84 513,16

UNIVERSITA DEGLI STUDI DI GENOVA

Italy

EU Contribution

€ 112 821,36

SERVICIO MADRILENO DE SALUD

Spain

EU Contribution

€ 107 893,24

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II

Italy

EU Contribution

€ 45 032,36

INSTITUT CATALA DE LA SALUT

Spain

EU Contribution

€ 56 265,54

SOCIETE EUROPEENNE DE CARDIOLOGIE

France

EU Contribution

€ 28 180

INFORSENSE LIMITED

United Kingdom

EU Contribution

€ 46 740,90

CFc srl

Italy

EU Contribution

€ 79 661,10

FONDAZIONE TOSCANA GABRIELE MONASTERIO PER LA RICERCA MEDICA E DI SANITA PUBBLICA

Italy

EU Contribution

€ 233 031,84

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN

Germany

EU Contribution

€ 98 962,99

QUEEN MARY UNIVERSITY OF LONDON

United Kingdom

EU Contribution

€ 120 247,88

AZIENDA OSPEDALIERO-UNIVERSITARIA CAREGGI

Italy

EU Contribution

€ 40 000

Azienda U.S.L. N. 12 di Viareggio

Italy

EU Contribution

€ 30 000

KLINIKEN DES LANDKREISES GOPPINGEN GGMBH

Germany

EU Contribution

€ 40 000

Project information

Grant agreement ID: 222915

Status

Closed project

  • Start date

    1 January 2009

  • End date

    30 June 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 432 418,46

  • EU contribution

    € 2 695 402

Coordinated by:

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

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