CORDIS
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A pharmacogenomic approach to coumarin anticoagulant therapy

Project information

Grant agreement ID: 223062

Status

Closed project

  • Start date

    1 October 2008

  • End date

    31 March 2013

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 575 385,60

  • EU contribution

    € 2 544 891

Coordinated by:

UNIVERSITEIT UTRECHT

Netherlands

Objective

The effectiveness of treatment with oral anticoagulants in the prevention of thrombotic disorders is well established, but these drugs are potentially dangerous because of their narrow therapeutic index. In Europe three coumarins are used: warfarin, acenocoumarol, and phenprocoumon. Genetic factors that have been recently demonstrated to change the pharmacokinetics and pharmacodynamics of coumarins are the presence of polymorphisms in the genes encoding for CYP2C9 and VKOR (vitamin K epoxide reductase complex). Polymorphisms in these genes are associated with increased risk for severe overanticoagulation and bleedings. A clinical trial will be performed in seven European countries to determine whether knowledge of the genotype of patients at the start of coumarin treatment will increase the safety of use of these compounds and whether such gene testing is cost-effective. Patients will be randomized to receive treatment with a coumarin either dosed with an algorithm that does not include information on their genotype, or with an algorithm that does contain this information. The primary outcome will be time within therapeutic INR range. Secondary outcomes include INR>4 and bleedings.
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Coordinator

UNIVERSITEIT UTRECHT

Address

Heidelberglaan 8
3584 Cs Utrecht

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 658 185

Administrative Contact

Rinske De Kok-Baan (Ms.)

Participants (11)

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

EU Contribution

€ 73 680

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 11 510,10

UNIVERSITAET ULM

Germany

EU Contribution

€ 154 858

UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

EU Contribution

€ 388 696

THE UNIVERSITY OF LIVERPOOL

United Kingdom

EU Contribution

€ 488 072

LGC LIMITED

United Kingdom

EU Contribution

€ 161 452

UNIVERSITE PARIS-SUD

France

UPPSALA UNIVERSITET

Sweden

EU Contribution

€ 309 541

DIMOKRITIO PANEPISTIMIO THRAKIS

Greece

EU Contribution

€ 224 904

ALLGEMEIN OFFENTLICHES KRANKENHAUS DER ELISABETHINEN

Austria

EU Contribution

€ 54 810

ERASMUS UNIVERSITEIT ROTTERDAM

Netherlands

EU Contribution

€ 19 182,90

Project information

Grant agreement ID: 223062

Status

Closed project

  • Start date

    1 October 2008

  • End date

    31 March 2013

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 575 385,60

  • EU contribution

    € 2 544 891

Coordinated by:

UNIVERSITEIT UTRECHT

Netherlands

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