Objective Whole-genome sequences and their annotation have enabled the reconstruction of genome-scale metabolic networks. Such network reconstructions form the foundation for systems analysis of metabolic functions in health and disease. Over the past ten years, a series of genome-scale reconstructions have been built for microorganisms. They have been demonstrated to be useful for developing a deeper understanding of physiological processes, drive discovery through computer generated hypothesis relating to missing parts of a network, to interpret the consequences of gene knock outs, and for metabolic engineering and bioprocess purposes. With build-35 of the human genome sequence it has proved to be possible to initiate the build of a similar genome-scale reconstruction of metabolism in man. Thus an era of systems biology analysis of human metabolic functions has just been opened, in an analogous fashion as happened for microorganisms about 10 years ago. This proposal describes a program that will lead this new era. Our three overall objectives are: 1) to continue to build the metabolic reconstruction in an iterative fashion as has been done for microorganisms in the past, 2) to deploy existing computer algorithms to systematically fill in gaps in our knowledge base about human metabolism, and 3) to use the reconstruction high-throughput data analysis and to begin the effort of drug screening and discovery for metabolic interventions. The PI has been active in this field for over 25 years, and, in fact, has been a leader in developing reconstruction technology, the computer methods that are used to characterize them, and bring them to practical uses. He has been particularly active in training young scientist in this field and been involved in translational research and company startups. Fields of science natural sciencescomputer and information sciencesdata scienceengineering and technologyindustrial biotechnologymetabolic engineeringnatural sciencesbiological sciencesgeneticsgenomesnatural sciencesbiological sciencesmicrobiology Keywords drug screening experimental discovery in silico modeling metabolism systems biology Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-AG-LS2 - ERC Advanced Grant - Genetics, Genomics, Bioinformatics and Systems Biology Call for proposal ERC-2008-AdG See other projects for this call Funding Scheme ERC-AG - ERC Advanced Grant Host institution HASKOLI ISLANDS EU contribution € 2 399 634,00 Address SAEMUNDARGOTU 2 101 Reykjavik Iceland See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Higher or Secondary Education Establishments Principal investigator Bernhard örn Palsson (Prof.) Administrative Contact ásta Sif Erlingsdóttir (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all HASKOLI ISLANDS Iceland EU contribution € 2 399 634,00 Address SAEMUNDARGOTU 2 101 Reykjavik See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Higher or Secondary Education Establishments Principal investigator Bernhard örn Palsson (Prof.) Administrative Contact ásta Sif Erlingsdóttir (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data