Objectif The development of new strategies that allow increasingly rapid access to structural complexity remains one of the fundamental challenge for the chemical sciences. While the total synthesis approach to molecular complexity is generally based on a costly sequence of individual reactions, it is intriguing to consider that biological systems produce elaborate molecules in an economic continuous process, wherein enzymatic transformations are combined in highly regulated catalytic cascades. Therefore in order to improve the production of complex molecules, lessons learned from Nature could be beneficial for the chemical synthesis. Over the past few years, the field of asymmetric organocatalysis has literally exploded. As one of the pioneering groups in the field, the MacMillan group has reported various groundbreaking catalytic asymmetric reactions based on organocatalysts of their original design. In 2005, MacMillan introduced for the first time the concept of enantioselective organo-cascade catalysis, a powerful strategy that provides rapid access to structural complexity from simple starting materials. In this proposal a strategic approach towards a total synthesis of 12-deoxy phorbol is viewed to demonstrate the applicability and the efficiency of cascade catalysis in the context of the total synthesis of natural products. By employing cascade catalysis in the key bond constructing manipulations, the synthesis of 12-deoxy phorbol, should be achieved in only one-third of the steps that had been required for previous synthetic studies of the phorbol skeleton. The return phase will be dedicated to a not less attractive and exciting field of chemistry where the access to structural complexity is also a challenge: the nanotechnology. This stay in the Leigh Group will allow the researcher to transfer her knowledge and expertise acquired in the field of synthetic organic chemistry to the development of the first organocatalytic active template synthesis of rotaxanes. Champ scientifique natural scienceschemical sciencesorganic chemistryengineering and technologynanotechnologynatural scienceschemical sciencescatalysis Mots‑clés Asymmetric catalysis Cascade reactions Homogeneous catalysis Nanotechnology Natural product synthesis Organic chemistry Organocatalysis rotaxanes Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) PEOPLE-2007-4-1.IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Appel à propositions FP7-PEOPLE-2007-4-1-IOF Voir d’autres projets de cet appel Régime de financement MC-IOF - International Outgoing Fellowships (IOF) Coordinateur THE UNIVERSITY OF EDINBURGH Contribution de l’UE € 155 104,54 Adresse OLD COLLEGE, SOUTH BRIDGE EH8 9YL Edinburgh Royaume-Uni Voir sur la carte Région Scotland Eastern Scotland Edinburgh Type d’activité Higher or Secondary Education Establishments Contact administratif Angela Noble (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire TRUSTEES OF PRINCETON UNIVERSITY États-Unis Contribution de l’UE Aucune donnée Adresse NASSAU HALL 1 08544-2001 Princeton, Nj Voir sur la carte Type d’activité Higher or Secondary Education Establishments Contact administratif Kathy Niebo (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée