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European Network on Directed Evolution of Functional Proteins

Objective

This project intends to use directed evolution as tool to reproduce Nature's remarkable ability to generate molecular machines - in particular enzymes – that perform at levels near perfection. By harnessing the forces of Darwinian evolution in the laboratory we want to (i) screen large and diverse genome libraries for protein with new and useful functions, (ii) optimize existing proteins for applications in medicine, biotechnology and cell biology and (iii) provide a better understanding of how existing enzymes evolved and study enzyme mechanisms in general. The proposed Network brings together leading academic and industrial groups with diverse and complementary skills: the development of a variety of innovative biotechnology tools for the generation and exploitation of large genomic and man-made libraries, expertise in mechanistic enzymology and an unrivalled technology platform including phage display, in vitro compartmentalization, ribosome display, selective protein labelling and high-throughput screening that will be key to achieve the ambitious goals of this project. The project is a continuation of a highly successful framework 5 network. The partnership has now been extended by two successful SMEs at different stages of their development and one of Europe’s premier medium-sized biotech companies that are keen to utilise and market the expected results of this collaborative effort.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/genetics and heredity/genome
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

FP7-PEOPLE-2007-1-1-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 351 280,49
Administrative Contact
Renata Schaeffer (Ms.)

Participants (9)

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Switzerland
EU contribution
€ 221 813,31
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Luciana Vaccaro (Ms.)
BEN-GURION UNIVERSITY OF THE NEGEV
Israel
EU contribution
€ 270 286,71
Address
.
84105 Beer Sheva
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dori Schneider (Ms.)
UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium
EU contribution
€ 262 925
Address
Place De L Universite 1
1348 Louvain La Neuve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Catherine Kinard (Ms.)
UNIVERSITAET GREIFSWALD
Germany
EU contribution
€ 157 422,60
Address
Domstrasse 11
17489 Greifswald
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Diana Lode
COVALYS BIOSCIENCES AG

Participation ended

Switzerland
EU contribution
€ 26 211
Address
Benkenstrasse 254
4108 Witterswil
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kathrin Muntener (Ms.)
Brain AG
Germany
EU contribution
€ 174 532,80
Address
Darmstädter Straße 34-36
64673 Zwingenberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Holger Zinke (Dr.)
MEDIMMUNE LIMITED
United Kingdom
EU contribution
€ 488 378,40
Address
Milstein Building Granta Park
CB21 6GH Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Amanda Dalton (Ms.)
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 213 303,69
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Geert-Jan Arends (Mr.)
UNIVERSITE DE STRASBOURG
France
EU contribution
€ 233 846
Address
Rue Blaise Pascal 4
67081 Strasbourg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sandrine Schott-Carriere (Ms.)