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Exploring Cellular Dynamics at Nanoscale

Objective

EXCELL is a novel innovative approach to explore interaction mechanisms between biological materials and systems/nanostructures. It involves a forward-looking cross-disciplinary and design-based research to generate an integrated, biologically inspired technological platform of high complexity, able to monitor cell dynamics at nano-scale. Expertise in cellular and molecular biology, nanosciences, material engineering, biophysics, biotechnology, modelling, and analytical chemistry, are combined to address the targeted goals, which go beyond the state of the art methods used in traditional biotechnology and systems biology. EXCELL will provide a complete Lab-in-a-Cell (LIC) sensor and actuator platform, which is capable of: (1) studying single cells in their natural environment surrounded by other cells or a complex mixture of different cells/tissue, (2) following the dynamics and interdependence of single cell processes from gene, protein, metabolite to compound secretion, exocytosis and cell-to-cell communication, (3) testing how and where various stimuli affect the different levels of the molecular machinery and finally (4) programming cells to be able to differentiate into a particular phenotype. A major task is the design of suitable biocompatible nano/bio interfaces that ensures a sustainable cellular environment. EXCELL provides a unique opportunity for developing advanced, novel experimental tools to address fundamental problems of stem cell research and poses a potential for possible diversification and modulation of developmental programs of stem cells to differentiate them into specific phenotypes. EXCELL has the capacity to drive new discoveries having a significant impact not only in the field of stem cell research and clinical use, but also on molecular engineering, nanosciences, sensor development, diagnostics, therapeutics, biotechnology and industry (smart materials, medical diagnostics, pharmaceutical companies, start-ups)

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /natural sciences/chemical sciences/analytical chemistry
  • /natural sciences/biological sciences/molecular biology
  • /natural sciences/biological sciences/biophysics

Call for proposal

FP7-NMP-2007-SMALL-1
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

DANMARKS TEKNISKE UNIVERSITET
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 788 000
Administrative Contact
Niels Freese (Mr.)

Participants (9)

MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 246 840
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Merab Kokaia (Prof.)
TEL AVIV UNIVERSITY
Israel
EU contribution
€ 515 600
Address
Ramat Aviv
69978 Tel Aviv
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lea Pais (Ms.)
UNIVERSIDAD AUTONOMA DE MADRID
Spain
EU contribution
€ 418 400
Address
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mª Carmen Puerta (Ms.)
TERMESZETTUDOMANYI KUTATOKOZPONT
Hungary
EU contribution
€ 220 940
Address
Magyar Tudosok Korutja 2
1117 Budapest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gábor Barlai (Mr.)
UNIVERSITA DEGLI STUDI DI GENOVA
Italy
EU contribution
€ 346 080
Address
Via Balbi 5
16126 Genova
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniele Caviglia (Prof.)
LUXCEL BIOSCIENCES LTD
Ireland
EU contribution
€ 329 010
Address
Biotransfer Unit Suite 3-32 Biol
T12 Cork
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Richard Fernandes (Dr.)
POLITECNICO DI MILANO
Italy
EU contribution
€ 344 280
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Fabio Conti (Mr.)
SCITECH LINK AB
Sweden
EU contribution
€ 285 200
Address
Borgaslingan 31
22472 Lund
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Elisabeth Csöregi (Dr.)
UNIVERSITAET POTSDAM
Germany
EU contribution
€ 286 400
Address
Am Neuen Palais 10
14469 Potsdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Regina Gerber (Dr.)