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Novel Polysaccharide Modifying Enzymes to Optimise the Potential of Hydrocolloids for Food and Medical Applications

Project information

Grant agreement ID: 222628

Status

Closed project

  • Start date

    1 May 2009

  • End date

    30 April 2013

Funded under:

FP7-KBBE

  • Overall budget:

    € 8 226 733,87

  • EU contribution

    € 5 999 948

Coordinated by:

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany

Objective

The PolyModE project convenes an international, interdisciplinary, and intersectorial consortium to identify, characterise, and optimise novel polysaccharide modifying enzymes, and to develop robust fermentation strategies for their large-scale production, to exploit the potential of biopolymers for food, pharmaceutical, cosmetic, and technical applications. We have selected the six complex carbohydrates with the highest current market share or expected future market potential, namely alginate, carrageenan, chitosan, glycosaminoglycan, pectin, and xanthan gum. For each of these, the industrial partners have identified those enzymes which will answer to the most pressing needs or offer the most promising potential for improved production of polysaccharides with novel physico-chemical properties and biological functionalities. Primary targets will be alginate epimerases, carrageenan sulfatases, chitosan de-acetylases, glycosaminoglycan sulfatases, pectin de-acetylases, and xanthan gum de-acetylases. These enzymes together with secondary target enzymes, e.g. sequence specific lyases and hydrolases, will allow the generation and analysis of polymers and oligomers with novel, non-random patterns of modification. Two parallel approaches will be followed for each type of polysaccharide modifying enzyme, namely a knowledge-based genomic approach and a broad, un-biased metagenomic approach, e.g. using soil or sludge samples with a history of contact with the polysaccharide in question. A pipeline of three levels of fermentation systems will be established, ranging from lab-scale innovative expression systems with features shaped according to the specific characteristics of our target enzymes, through medium-scale, novel and unusual fermentation systems provided by a number of SME with highly specialised knowledge and expertise in developing and using such systems, to the established large-scale fermentation systems and facilities of market leaders in White Biotechnology.

Coordinator

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Address

Schlossplatz 2
48149 Munster

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 050 192

Administrative Contact

Bruno Moerschbacher (Prof.)

Participants (14)

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT

France

EU Contribution

€ 699 600

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 729 248

WAGENINGEN UNIVERSITY

Netherlands

EU Contribution

€ 747 208

SVERIGES LANTBRUKSUNIVERSITET

Sweden

EU Contribution

€ 566 000

THE STEPHAN ANGELOFF INSTITUTE OF MICROBIOLOGY, BULGARIAN ACADEMY OF SCIENCES

Bulgaria

EU Contribution

€ 434 000

DUPONT NUTRITION BIOSCIENCES APS

Denmark

EU Contribution

€ 591 500

SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT

France

EU Contribution

€ 135 000

GILLET CHITOSAN EURL

France

EU Contribution

€ 60 000

GENEART AG

Germany

EU Contribution

€ 216 000

LIBRAGEN

France

EU Contribution

€ 120 000

ARTES BIOTECHNOLOGY GmbH

Germany

EU Contribution

€ 120 000

GTP TECHNOLOGY SA

France

EU Contribution

€ 124 800

LYON INGENIERIE PROJETS

France

EU Contribution

€ 323 200

PETRA TEWES-SCHWARZER - CARE SENSE CONSULTING

Germany

EU Contribution

€ 83 200

Project information

Grant agreement ID: 222628

Status

Closed project

  • Start date

    1 May 2009

  • End date

    30 April 2013

Funded under:

FP7-KBBE

  • Overall budget:

    € 8 226 733,87

  • EU contribution

    € 5 999 948

Coordinated by:

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany