Objective The question of how the shape and size multicellular organs is controlled is a basic question in biology. In plants, recent work from the Fleming lab has indicated that cells around the periphery of the organ (the margin cells) play a special role in influencing leaf size and shape. The peculiar shape of these cells raises the possibility that they play a mechanical role in constraining leaf size and shape. The aim of this project is to further investigate the function of cells at the leaf margin in controlling leaf size and shape and, in particular, to investigate the potential biomechanical function of these cells. The project will require expertise in specific areas of molecular biology (which I already have) and expertise in the quantitative analysis of organ size and shape (involving computational approaches) which I will learn in the host lab. The scientific output of the proposed research will be insight into a basic aspect of developmental biology, particularly the emerging area of molecular biology and mechanics. Fields of science natural sciencesbiological sciencesdevelopmental biologynatural sciencesbiological sciencesmolecular biology Keywords Molecular genetics leaf development leaf size and shape Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-IEF-2008 - Marie Curie Action: "Intra-European Fellowships for Career Development" Call for proposal FP7-PEOPLE-IEF-2008 See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator THE UNIVERSITY OF SHEFFIELD EU contribution € 181 350,76 Address FIRTH COURT WESTERN BANK S10 2TN Sheffield United Kingdom See on map Region Yorkshire and the Humber South Yorkshire Sheffield Activity type Higher or Secondary Education Establishments Administrative Contact Tracey Swift (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data