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Novel Approaches to Bacterial Target Identification, Validation and Inhibition

Objective

Despite the advent of the antibiotic era, infectious diseases retain their pre-eminent position as major worldwide causes of morbidity and mortality. This problem has been worsen by the emergence of multi-antibiotic resistant bacteria and the failure of Pharmaceutical company drug discovery programmes to design antibiotics with truly novel modes of action. NABATIVI has put together a unique consortium made of six academic insitutions and three highly recognized SMEs with complementary expertise in the fields of molecular pathogenicity and broad expertise in drug discovery, optimisation, preclinical development. The consortium has been specifically designed to generate new strategies leading to the identification and validation of novel targets for antimicrobials using as model organisms the gram-negatives Pseudomonas aeruginosa and Burkholderia cenocepacia as they are key agents of morbidity and mortality worldwide in a wide range of diseases. The versatility of these model bacteria will enable the results obtained to be extrapolated to other bacterial pathogens. The extensive involvement of SMEs in this consortium will enable the selection of lead compounds against the identified targets from their large libraries of natural and synthetic chemicals which after validation will establish the basis for the development of new classes of antibacterial drugs. This will result in a reduction in the incidence and improvement of the treatment of infections caused by these organisms with a direct impact on the quality of life and the life expectancy of the affected risk patient populations.

Field of science

  • /medical and health sciences/health sciences/infectious disease
  • /social sciences/sociology/demography/mortality

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project
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Coordinator

UNIVERSITA VITA-SALUTE SAN RAFFAELE
Address
Via Olgettina 58
20132 Milano
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 610 529
Administrative Contact
Maria Rosa Pedrazzi (Dr.)

Participants (9)

THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 681 600
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Cartledge (Mr.)
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
EU contribution
€ 618 960
Address
Geschwister-scholl-platz
72074 Tuebingen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerd Döring (Prof.)
ACTAR AB
Sweden
EU contribution
€ 524 860
Address
Nobels Vaeg 3
171 77 Stockholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva Montgomerie (Ms.)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 674 800
Address
Ramistrasse 71
8006 Zürich
Activity type
Other
Administrative Contact
John Robinson (Prof.)
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 699 600
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stefania Varotto (Ms.)
GREENPHARMA S.A.
France
EU contribution
€ 527 600
Address
Allée Du Titane 3
45100 Orléans
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jean-Yves Berthon (Dr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 522 880
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivan Kristoffersen (Mr.)
Polyphor AG
Switzerland
EU contribution
€ 341 500
Address
Hegenheimermattweg
4123 Allschwil
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christian Ludin (Dr.)
FONDAZIONE CENTRO SAN RAFFAELE
Italy
EU contribution
€ 303 671
Address
Via Olgettina 60
20132 Milano
Activity type
Research Organisations
Administrative Contact
Maria Rosa Pedrazzi (Dr.)