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Traditional Chinese Medicine in the Post-genomic era: identifying lead therapeutic compounds against cancer

Traditional Chinese Medicine in the Post-genomic era: identifying lead therapeutic compounds against cancer

Objective

This application aims at identifying and characterizing a set of lead therapeutic compounds against cancer (breast, lung and brain), based on current knowledge from Traditional Chinese Medicine (TCM). TCM has a very long tradition in the prevention and treatment of a variety of diseases yet, in contrast to target-oriented Western medicine, TCM uses a holistic and synergistic approach, which can be very effective for complex medical problems. However, the exact composition of the compounds that exert the therapeutic effect is not known. As there is little understanding about the mechanisms of action of many TCM therapies, modern and multidisciplinary Biotech research (functional genomics/ systems biology) should be applied on appropriate and highly defined cancer models. The presented project will focus on the isolation and characterization of chemical compounds from TCM that show anti-tumoral efficacy. From a library of therapeutic compounds available, a set of lead therapeutic substances will be identified using high throughput screening technologies in appropriate preclinical cancer models. Moreover, their mechanism of action will be further studied using genome wide analyses. Finally, their therapeutic efficacy will be tested in appropriate animal models.
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Coordinator

LUXEMBOURG INSTITUTE OF HEALTH

Address

Val Fleuri 84
1526 Luxembourg

Luxembourg

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 237 600

Administrative Contact

Daniel Cardao (Mr.)

Project information

Grant agreement ID: 230232

Status

Closed project

  • Start date

    1 March 2009

  • End date

    28 February 2013

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 237 600

  • EU contribution

    € 237 600

Coordinated by:

LUXEMBOURG INSTITUTE OF HEALTH

Luxembourg