CORDIS
EU research results

CORDIS

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Optimization of stem cell therapy for clinical trials of degenerative skin and muscle diseases

Project information

Grant agreement ID: 223098

Status

Closed project

  • Start date

    1 January 2009

  • End date

    31 December 2013

Funded under:

FP7-HEALTH

  • Overall budget:

    € 16 564 311,99

  • EU contribution

    € 11 992 312

Coordinated by:

UNIVERSITA DEGLI STUDI DI MILANO

Italy

Objective

This proposal aims to develop and implement efficacy of clinical trials with adult, tissue stem cells for degenerative diseases of epithelia and skeletal muscle. Extraordinary progress in the understanding of several key features of stem cells has been rapidly translated into novel cell therapy protocols that have yielded positive results in pre-clinical models of genetic and acquired diseases and in the first clinical trials. Much remains to be done on the basic biology of stem cells to provide new tools for cell therapy trials. Also transplantation related issues, such as engraftment, angiogenesis, tissue remodeling and immune response remain to be addressed. In general, cell therapy necessitates a continuous cross-talk among biologists and clinicians as well as crossing boundaries among different tissues/diseases. Despite many structural and functional differences, epithelia and skeletal muscle share some key features such as spatially ordered cell architecture, centered on a supporting basal lamina to which stem cells are anchored. Indeed mutations in structural proteins linking the cell membrane to the basal lamina are responsible for similarly devastating diseases such as muscular dystrophies and epidermolysis bullosa. A multi-tissue approach allows jointly addressing and solving not only scientific and clinical problems but also regulatory and ethical issues related to these novel procedures. Finally, sharing high valued dedicated platforms such as large animal facilities and GMP cell culture facilities increases performance and reduces costs. Based on these considerations, a network of internationally recognized experts in muscle and epithelial cell biology, immunology, angiogenesis, and molecular pharmacology with two stem cell-based Companies has been assembled, creating a synergistic approach that will increase the chance of success for ongoing and future clinical trials with stem cells, that are integral part of this proposal.
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Coordinator

UNIVERSITA DEGLI STUDI DI MILANO

Address

Via Festa Del Perdono 7
20122 Milano

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 242 584,52

Administrative Contact

Mario Ferrante (Dr.)

Participants (19)

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

EU Contribution

€ 751 700

THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 1 239 452

INSTITUT PASTEUR

France

EU Contribution

€ 872 900

IFOM FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE

Italy

EU Contribution

€ 410 900

UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA

Italy

EU Contribution

€ 1 659 000

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 510 500

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 476 900

Fondazione Centro San Raffaele

Italy

CANCER RESEARCH UK LBG

United Kingdom

EU Contribution

€ 250 001,48

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 758 974

IRCCS - ASSOCIAZIONE LA NOSTRA FAMIGLIA 'ISTITUTO SCIENTIFICO EUGENIO MEDEA'

Italy

EU Contribution

€ 410 900

MOLECULAR MEDICINE SPA

Italy

EU Contribution

€ 758 900

DANDO WEISS & COLUCCI LIMITED

United Kingdom

EU Contribution

€ 471 000

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS

Switzerland

EU Contribution

€ 369 200

UNIVERSIDAD POMPEU FABRA

Spain

EU Contribution

€ 410 900

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH

Germany

EU Contribution

€ 70 400

MILTENYI BIOTEC GMBH

Germany

EU Contribution

€ 620 200

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 324 000

FONDAZIONE CENTRO SAN RAFFAELE

Italy

EU Contribution

€ 383 900

Project information

Grant agreement ID: 223098

Status

Closed project

  • Start date

    1 January 2009

  • End date

    31 December 2013

Funded under:

FP7-HEALTH

  • Overall budget:

    € 16 564 311,99

  • EU contribution

    € 11 992 312

Coordinated by:

UNIVERSITA DEGLI STUDI DI MILANO

Italy