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OBesogenic Endocrine disrupting chemicals: LInking prenatal eXposure to the development of obesity later in life

Objective

The incidence of childhood obesity has reached ‘epidemic’ proportions globally and there is an urgent need to increase our understanding of the impact of food contaminants on obesity development. The OBELIX project will examine the hypothesis that prenatal exposure to endocrine disrupting compounds (EDCs) in food plays a role in the development of obesity later in life. OBELIX proposes a multidisciplinary approach that combines epidemiology, neonatology, endocrinology, toxicology, analytical chemistry and risk assessment to address the objectives of the project: 1) To assess prenatal exposure in humans to major classes of EDCs in food identified as potential inducers of obesity (i.e. dioxins, non- and dioxin-like polychlorinated biphenyls, brominated flame retardants, phthalates and perfluorinated alkyl acids) using mother-child cohorts from four European regions with different food contaminant exposure patterns; 2) To relate early life exposure to EDCs with clinical markers, novel biomarkers and health effect data related to obesity; 3) To perform hazard characterization of in utero exposure to EDCs for the development of obesity later in life, using dose-response analysis in a rodent model; 4) To determine mechanisms of action of obesogenic EDCs on developmental programming with genomics and epigenetic analysis in in vivo and in vitro models; and, 5) to perform risk assessment of prenatal exposure to obesogenic EDCs in food, by integrating maternal exposure through food, contaminant exposure and health effect data in children, and hazard data. The outcomes of OBELIX are of particular relevance to the Work Programme, as the proposed project will generate new knowledge about prenatal exposure to major classes of EDCs in food that are potential inducers of obesity and related metabolic diseases later in life. It will also contribute new knowledge about effects of early exposure to EDCs on human health, including causality in animal models and possible mechanisms.

Call for proposal

FP7-KBBE-2008-2B
See other projects for this call

Coordinator

STICHTING VU
Address
De Boelelaan 1105
1081 HV Amsterdam
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 980 064
Administrative Contact
Yvonne Kops (Dr.)

Participants (7)

VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.
Belgium
EU contribution
€ 616 895
Address
Boeretang 200
2400 Mol
Activity type
Research Organisations
Administrative Contact
Greet Schoeters (Prof.)
RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU
Netherlands
EU contribution
€ 808 460
Address
Antonie Van Leeuwenhoeklaan 9
3721 MA Bilthoven
Activity type
Research Organisations
Administrative Contact
Remco Van Den Dikkenberg (Mr.)
FOLKEHELSEINSTITUTTET
Norway
EU contribution
€ 264 138
Address
Lovisenberggata 8
0456 Oslo
Activity type
Research Organisations
Administrative Contact
Frederik Froen (Mr.)
STICHTING ECOBABY
Netherlands
EU contribution
€ 29 088
Address
Hollandstraat 6
3634 AT Loenersloot
Activity type
Research Organisations
Administrative Contact
Aart Blom (Dr.)
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 101 047
Address
147 Rue De L'universite
75007 Paris Cedex 07
Activity type
Research Organisations
Administrative Contact
Jean-Jacques Petitdidier (Mr.)
SLOVENSKA ZDRAVOTNICKA UNIVERZITA V BRATISLAVE
Slovakia
EU contribution
€ 200 000
Address
Limbova 12
83303 Bratislava
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Milan Cagan (Ms.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margot Rijerse (Ms.)