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A comprehensive dissection of pneumococcal-host interactions

Objective

This project is a fundamental, comprehensive study of the host-pathogen interactions during infection with Streptococcus pneumoniae. The expectation is that the basic knowledge gained from this work will give new targets for vaccination, diagnosis and treatment. In PNEUMOPATH, academic and industrial partners will work together in six scientific workpackages. 1) The molecular epidemiology of antibiotic resistant pneumococci 2) The genetic basis of disease susceptibility in the human host and in mice 3) Molecular aspects of virulence and host response in animal models of pneumococcal carriage and disease 4) Molecular aspects of virulence and host response in human cell culture systems 5) Pneumococcal cell biology to determine the role of central metabolic processes and the link to virulence 6) Integrated bioinformatics and data management It is accepted that the outcome of pneumococcal infection is determined by the interplay of both host and pathogen attributes. Pneumococcal isolates vary in the repertoire of genes that they possess. Hence the contribution of an individual factor to the infectious process may vary according to the other host and pathogen factors that are present. To date, study of infection has tended to be a reductionist approach, considering the contribution of each virulence factor or host factor in isolation. Consequently, in searching for targets for antimicrobial therapy or for enhancement of host defence, the contribution of individual factors may be inaccurately estimated. This project will be radically different. Rather than using targeted mutagenesis to create strains of different phenotype for testing, PNEUMOPATH will be a systems biology approach with a checkerboard experimental design Panels of resistant/non-resistant carriage and disease pneumococcal isolates will be used to challenge in vivo and in vitro models, followed by integrated management and analysis of the data with a new semantic web bioinformatic infrastructure.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /natural sciences/computer and information sciences/internet/semantic web
  • /medical and health sciences/health sciences/epidemiology

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITY OF LEICESTER
Address
University Road
LE1 7RH Leicester
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 503 783
Administrative Contact
Marie Adams (Ms.)

Participants (14)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 346 890
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Armelle Barelli (Ms.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 346 740
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Guido L.M. Van Den Bogaert (Mr.)
SMITTSKYDDSINSTITUTET
Sweden
EU contribution
€ 300 000
Address
Nobels Vaeg 18
17182 Solna
Activity type
Research Organisations
Administrative Contact
Birgitta Henriques Normark (Prof.)
ISLENSK ERFDAGREINING EHF
Iceland
EU contribution
€ 284 353
Address
Sturlugotu 8
101 Reykjavik
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bjorgvin Richardsson (Mr.)
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 285 500
Address
Via Banchi Di Sotto 55
53100 Siena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Silvano Focardi (Prof.)
TECHNISCHE UNIVERSITAT KAISERSLAUTERN
Germany
EU contribution
€ 149 496
Address
Gottlieb Daimler Strasse
67663 Kaiserslautern
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Berthold Klein (Mr.)
INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA
Portugal
EU contribution
€ 150 000
Address
Avenida Da Republica, Estacao Agronomica Nacional
2784-505 Oeiras
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margarida Martinez (Dr.)
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 157 500
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Poutsma
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE
France
EU contribution
€ 152 400
Address
Avenue De Rangueil 135
31077 Toulouse
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Elena Grigoras (Ms.)
INESC ID - INSTITUTO DE ENGENHARIADE SISTEMAS E COMPUTADORES, INVESTIGACAO E DESENVOLVIMENTO EM LISBOA
Portugal
EU contribution
€ 149 977
Address
Rua Alves Redol 9
1000 029 Lisboa
Activity type
Research Organisations
Administrative Contact
Jonas Almeida (Prof.)
Intercell AG
Austria
EU contribution
€ 15 000
Address
Campus Vienna Biocenter 3
1030 Vienna
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eva Schabl (Ms.)
MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 8 200
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Hilary Gates (Dr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 150 000
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Staffan Normark (Prof.)
IQ CORPORATION BV
Netherlands
Address
Rozenburglaan 13A
9747 DL Groningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roland Lageveen (Dr.)