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A comprehensive dissection of pneumococcal-host interactions

A comprehensive dissection of pneumococcal-host interactions

Objective

This project is a fundamental, comprehensive study of the host-pathogen interactions during infection with Streptococcus pneumoniae. The expectation is that the basic knowledge gained from this work will give new targets for vaccination, diagnosis and treatment. In PNEUMOPATH, academic and industrial partners will work together in six scientific workpackages. 1) The molecular epidemiology of antibiotic resistant pneumococci 2) The genetic basis of disease susceptibility in the human host and in mice 3) Molecular aspects of virulence and host response in animal models of pneumococcal carriage and disease 4) Molecular aspects of virulence and host response in human cell culture systems 5) Pneumococcal cell biology to determine the role of central metabolic processes and the link to virulence 6) Integrated bioinformatics and data management It is accepted that the outcome of pneumococcal infection is determined by the interplay of both host and pathogen attributes. Pneumococcal isolates vary in the repertoire of genes that they possess. Hence the contribution of an individual factor to the infectious process may vary according to the other host and pathogen factors that are present. To date, study of infection has tended to be a reductionist approach, considering the contribution of each virulence factor or host factor in isolation. Consequently, in searching for targets for antimicrobial therapy or for enhancement of host defence, the contribution of individual factors may be inaccurately estimated. This project will be radically different. Rather than using targeted mutagenesis to create strains of different phenotype for testing, PNEUMOPATH will be a systems biology approach with a checkerboard experimental design Panels of resistant/non-resistant carriage and disease pneumococcal isolates will be used to challenge in vivo and in vitro models, followed by integrated management and analysis of the data with a new semantic web bioinformatic infrastructure.
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Coordinator

UNIVERSITY OF LEICESTER

Address

University Road
Le1 7rh Leicester

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 503 783

Administrative Contact

Marie Adams (Ms.)

Participants (14)

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 346 890

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

EU Contribution

€ 346 740

SMITTSKYDDSINSTITUTET

Sweden

EU Contribution

€ 300 000

ISLENSK ERFDAGREINING EHF

Iceland

EU Contribution

€ 284 353

UNIVERSITA DEGLI STUDI DI SIENA

Italy

EU Contribution

€ 285 500

TECHNISCHE UNIVERSITAET KAISERSLAUTERN

Germany

EU Contribution

€ 149 496

INSTITUTO DE TECNOLOGIA QUIMICA E BIOLOGICA - UNIVERSIDADE NOVA DE LISBOA

Portugal

EU Contribution

€ 150 000

RIJKSUNIVERSITEIT GRONINGEN

Netherlands

EU Contribution

€ 157 500

INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE

France

EU Contribution

€ 152 400

INESC ID - INSTITUTO DE ENGENHARIADE SISTEMAS E COMPUTADORES, INVESTIGACAO E DESENVOLVIMENTO EM LISBOA

Portugal

EU Contribution

€ 149 977

Intercell AG

Austria

EU Contribution

€ 15 000

MEDICAL RESEARCH COUNCIL

United Kingdom

EU Contribution

€ 8 200

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 150 000

IQ CORPORATION BV

Netherlands

Project information

Grant agreement ID: 222983

Status

Closed project

  • Start date

    1 March 2009

  • End date

    31 August 2012

Funded under:

FP7-HEALTH

  • Overall budget:

    € 4 149 765

  • EU contribution

    € 2 999 839

Coordinated by:

UNIVERSITY OF LEICESTER

United Kingdom