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Genomic Regulatory Systems of Human X-linked neurological diseases

Objective

NeuroXsys will generate regulatory maps and models of the human X chromosome based on evolutionary conservation, with special attention to genes and regions implicated in X-linked neurological diseases. Vertebrate chromosomes are subdivided into domains of genomic regulatory blocks (GRBs) and NeuroXsys aims to map all GRBs on the X chromosome through bioinformatic approaches, extract gene regulatory sequences, and model their activity through transgenic reporter assays in the zebrafish juvenile and adult brain. One of the major deliverables of this project will be the publication of an online database that achieves correlation of disease genes ordered with respect to their regulatory regions and their experimentally and bioinformatically assessed function. NeuroXsys will seek to identify human disease mutations in neural gene regulatory elements. Implicated elements will be studied as regulators at single cell resolution in the zebrafish and mouse brain, defining expression patterns driven by the normal and mutant human regulatory DNA sequences. NeuroXsys will generate a regulatory map of a human chromosome.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/chromosome
  • /natural sciences/physical sciences/astronomy/observational astronomy/gamma-ray astronomy

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITETET I BERGEN
Address
Museplassen 1
5020 Bergen
Norway
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 423 735
Administrative Contact
Inger Gjesdahl (Ms.)

Participants (8)

MEDICAL RESEARCH COUNCIL
United Kingdom
EU contribution
€ 152 236
Address
North Star Avenue Polaris House 2 Floor David Phillips Building
SN2 1FL Swindon
Activity type
Research Organisations
Administrative Contact
Kate Wilson (Dr.)
University College London
United Kingdom
EU contribution
€ 309 598
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Browne (Mr.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Participation ended

Germany
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Juergen Ertel (Dr.)
ECOLE NORMALE SUPERIEURE
France
EU contribution
€ 247 779
Address
45, Rue D'ulm
75230 Paris Cedex 05
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Nathalie Majua (Ms.)
KARLSRUHER INSTITUT FUER TECHNOLOGIE
Germany
EU contribution
€ 520 361
Address
Kaiserstrasse 12
76131 Karlsruhe
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Natascha Wallburg (Ms.)
THE UNIVERSITY OF SYDNEY
Australia
EU contribution
€ 651 803
Address
Camperdown Campus Arundel St 71/79
2006 Sydney
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jodie Sirone (Ms.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 448 481
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Michele Saumon (Ms.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 243 204
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Valerie Renton (Ms.)