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Metastatic tumours facilitated by hypoxic tumour micro-environments

Objective

Recent research suggests that the hypoxic micro-environment of tumours is one of the major drivers of metastatic spread of cancer. Furthermore, hypoxic tumour micro-environments may result in treatment resistance of cancer cells, therefore causing a double effect of reducing the potential of a successful treatment of the cancer patient. This project seeks to clarify the roles and functions of the hypoxic tumour micro-environment in relation to the survival of solid tumours likely to metastasise. We will gain new knowledge about molecular mechanisms behind hypoxia-driven metastasis, like the epithelial-mesenchymal transition (EMT) by several routes: (a): mechanisms related to cell growth- and cell proliferation (UPR, mTOR, CA9, HIF, Notch, and VHL), (b): angiogenesis and lymphangiogenesis, (c): metabolism and pH-regulation (d): the handling of reactive oxygen species (ROS). We will generate animal models for the study of the role of hypoxia in metastases and develop a bio-bank of tumour and blood samples for molecular diagnostic studies. We will identify and develop advanced imaging techniques and biomarkers and identify micro-metastases in bone marrow of patients to assist in the selection of appropriate stratification of the actual primary tumour’s and metastases’ micro-environmental conditions. We will also create a machine-learning based classifier of tumour hypoxia. The consortium has the necessary expertise to perform proof-of-principle clinical testing of new treatment strategies. We will thus perform clinical tests of new drugs developed to attack the regulatory mechanisms selected from the pre-clinical work and possible synergisms of combined treatments. We will also test new radiotherapy strategies for treatment of primary as well as metastatic tumours. Cancer types chosen for clinical studies are non-small-cell lung carcinoma, squamous cell carcinoma of the larynx, prostate cancer, primary breast cancer and rectal cancer.

Field of science

  • /medical and health sciences/clinical medicine/oncology/cancer/skin cancer/squamous cell carcinoma
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/prostate cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/skin cancer

Call for proposal

FP7-HEALTH-2007-B
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

UNIVERSITETET I OSLO
Address
Problemveien 5-7
0313 Oslo
Norway
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 192 200
Administrative Contact
Lars Bernhardsen (Mr.)

Participants (20)

STICHTING MAASTRICHT RADIATION ONCOLOGY MAASTRO CLINIC
Netherlands
EU contribution
€ 471 800
Address
Dr. Tanslaan 12
6229 ET Maastricht
Activity type
Research Organisations
Administrative Contact
Harald Moonen (Dr.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 648 100
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Angela Noble (Ms.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 572 500
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wim Bruinenberg (Mr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 584 500
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tina Almyroudi (Ms.)
AARHUS UNIVERSITETSHOSPITAL
Denmark
EU contribution
€ 574 900
Address
Palle Juul-jensens Boulevard 99
8200 Aarhus
Activity type
Research Organisations
Administrative Contact
Lene Spliid (Ms.)
FMC BIOPOLYMER AS
Norway
EU contribution
€ 296 500
Address
Industriveien 33
1337 Sandvika
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Tom Sandvoll (Mr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 746 500
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kerry Chantrey (Ms.)
UNIVERSITA DEGLI STUDI DI FIRENZE
Italy
EU contribution
€ 547 300
Address
Piazza San Marco 4
50121 Florence
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Antonio Bianchi (Prof.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 775 100
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Riitta Ljungström (Ms.)
UNIVERSIDAD AUTONOMA DE MADRID
Spain
EU contribution
€ 420 100
Address
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Carmen Puerta (Ms.)
DEUTSCHES HERZZENTRUM MUNCHEN
Germany
EU contribution
€ 427 300
Address
Lazarettstrasse 36
80636 Munich
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Ulrike Folkerts (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 428 500
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Hélène Faradji (Dr.)
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 429 700
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerald Urban (Prof.)
JOBST TECHNOLOGIES GMBH
Germany
EU contribution
€ 295 300
Address
Engesserstrasse 4 B
79108 Freiburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Gerhard Jobst (Mr.)
ViVoX ApS
Denmark
EU contribution
€ 298 900
Address
Gustav Wieds Vej 10
DK-8000 Aarhus
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jan Alexander Villadsen (Mr.)
University College London
United Kingdom
EU contribution
€ 373 200
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
VIROLOGICKY USTAV SLOVENSKEJ AKADEMIE VIED
Slovakia
EU contribution
€ 412 900
Address
Dubravska Cesta 9
84505 Bratislava
Activity type
Research Organisations
Administrative Contact
Irena Ginzeryova
VILNIAUS UNIVERSITETAS
Lithuania
EU contribution
€ 279 700
Address
Universiteto G. 3
01513 Vilnius
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Leonas Pasakarnis (Mr.)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 438 300
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sietske Satijn (Ms.)
OSLO UNIVERSITETSSYKEHUS HF
Norway
EU contribution
€ 785 000
Address
Kirkeveien 166 Tarnbygget
0450 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kristian Berg (Dr.)