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Metastatic tumours facilitated by hypoxic tumour micro-environments

Ziel

Recent research suggests that the hypoxic micro-environment of tumours is one of the major drivers of metastatic spread of cancer. Furthermore, hypoxic tumour micro-environments may result in treatment resistance of cancer cells, therefore causing a double effect of reducing the potential of a successful treatment of the cancer patient. This project seeks to clarify the roles and functions of the hypoxic tumour micro-environment in relation to the survival of solid tumours likely to metastasise. We will gain new knowledge about molecular mechanisms behind hypoxia-driven metastasis, like the epithelial-mesenchymal transition (EMT) by several routes: (a): mechanisms related to cell growth- and cell proliferation (UPR, mTOR, CA9, HIF, Notch, and VHL), (b): angiogenesis and lymphangiogenesis, (c): metabolism and pH-regulation (d): the handling of reactive oxygen species (ROS). We will generate animal models for the study of the role of hypoxia in metastases and develop a bio-bank of tumour and blood samples for molecular diagnostic studies. We will identify and develop advanced imaging techniques and biomarkers and identify micro-metastases in bone marrow of patients to assist in the selection of appropriate stratification of the actual primary tumour’s and metastases’ micro-environmental conditions. We will also create a machine-learning based classifier of tumour hypoxia. The consortium has the necessary expertise to perform proof-of-principle clinical testing of new treatment strategies. We will thus perform clinical tests of new drugs developed to attack the regulatory mechanisms selected from the pre-clinical work and possible synergisms of combined treatments. We will also test new radiotherapy strategies for treatment of primary as well as metastatic tumours. Cancer types chosen for clinical studies are non-small-cell lung carcinoma, squamous cell carcinoma of the larynx, prostate cancer, primary breast cancer and rectal cancer.

Aufforderung zur Vorschlagseinreichung

FP7-HEALTH-2007-B
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

CP-IP - Large-scale integrating project

Koordinator

UNIVERSITETET I OSLO
Adresse
Problemveien 5-7
0313 Oslo
Norwegen
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 2 192 200
Kontakt Verwaltung
Lars Bernhardsen (Mr.)

Beteiligte (20)

STICHTING MAASTRICHT RADIATION ONCOLOGY MAASTRO CLINIC
Niederlande
EU-Beitrag
€ 471 800
Adresse
Dr. Tanslaan 12
6229 ET Maastricht
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Harald Moonen (Dr.)
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU-Beitrag
€ 648 100
Adresse
Old College, South Bridge
EH8 9YL Edinburgh
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Angela Noble (Ms.)
STICHTING RADBOUD UNIVERSITEIT
Niederlande
EU-Beitrag
€ 572 500
Adresse
Houtlaan 4
6525 XZ Nijmegen
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Wim Bruinenberg (Mr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU-Beitrag
€ 584 500
Adresse
Wellington Square University Offices
OX1 2JD Oxford
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Tina Almyroudi (Ms.)
AARHUS UNIVERSITETSHOSPITAL
Dänemark
EU-Beitrag
€ 574 900
Adresse
Palle Juul-jensens Boulevard 99
8200 Aarhus
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Lene Spliid (Ms.)
FMC BIOPOLYMER AS
Norwegen
EU-Beitrag
€ 296 500
Adresse
Industriveien 33
1337 Sandvika
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Tom Sandvoll (Mr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU-Beitrag
€ 746 500
Adresse
Oxford Road
M13 9PL Manchester
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Kerry Chantrey (Ms.)
UNIVERSITA DEGLI STUDI DI FIRENZE
Italien
EU-Beitrag
€ 547 300
Adresse
Piazza San Marco 4
50121 Florence
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Antonio Bianchi (Prof.)
KAROLINSKA INSTITUTET
Schweden
EU-Beitrag
€ 775 100
Adresse
Nobels Vag 5
17177 Stockholm
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Riitta Ljungström (Ms.)
UNIVERSIDAD AUTONOMA DE MADRID
Spanien
EU-Beitrag
€ 420 100
Adresse
Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Maria Carmen Puerta (Ms.)
DEUTSCHES HERZZENTRUM MUNCHEN
Deutschland
EU-Beitrag
€ 427 300
Adresse
Lazarettstrasse 36
80636 Munich
Aktivitätstyp
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Kontakt Verwaltung
Ulrike Folkerts (Dr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Frankreich
EU-Beitrag
€ 428 500
Adresse
Rue Michel Ange 3
75794 Paris
Aktivitätstyp
Other
Kontakt Verwaltung
Hélène Faradji (Dr.)
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Deutschland
EU-Beitrag
€ 429 700
Adresse
Fahnenbergplatz
79098 Freiburg
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Gerald Urban (Prof.)
JOBST TECHNOLOGIES GMBH
Deutschland
EU-Beitrag
€ 295 300
Adresse
Engesserstrasse 4 B
79108 Freiburg
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Gerhard Jobst (Mr.)
ViVoX ApS
Dänemark
EU-Beitrag
€ 298 900
Adresse
Gustav Wieds Vej 10
DK-8000 Aarhus
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Jan Alexander Villadsen (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU-Beitrag
€ 373 200
Adresse
Gower Street
WC1E 6BT London
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Greta Borg-Carbott (Ms.)
VIROLOGICKY USTAV SLOVENSKEJ AKADEMIE VIED
Slowakei
EU-Beitrag
€ 412 900
Adresse
Dubravska Cesta 9
84505 Bratislava
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Irena Ginzeryova
VILNIAUS UNIVERSITETAS
Litauen
EU-Beitrag
€ 279 700
Adresse
Universiteto G. 3
01513 Vilnius
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Leonas Pasakarnis (Mr.)
UNIVERSITEIT MAASTRICHT
Niederlande
EU-Beitrag
€ 438 300
Adresse
Minderbroedersberg 4
6200 MD Maastricht
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Sietske Satijn (Ms.)
OSLO UNIVERSITETSSYKEHUS HF
Norwegen
EU-Beitrag
€ 785 000
Adresse
Kirkeveien 166 Tarnbygget
0450 Oslo
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Kristian Berg (Dr.)