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Overlooked Unresolved Toxic Organic Pollutants: Resolution, Identification, Measurement and Toxicity:OUTREACH

Overlooked Unresolved Toxic Organic Pollutants: Resolution, Identification, Measurement and Toxicity:OUTREACH

Objective

Organic pollution exceeds an area greater than that of France+Germany. Toxic, persistent, unresolved and unidentified, complex mixtures (UCMs) of organic chemicals are abundant all over the globe. These UCMs, which encompass a number of chemical classes, are outside present EU and world pollutant regulations. It is very important that these toxicants are identified, measured and their effects studied. Until recent work in my lab, few methods allowed such UCMs to be identified. Even now, we have only made studies of unresolved alkylated derivatives of benzene; there are numerous other unstudied classes of UCM chemicals widespread in the environment. These will be amenable to study by the new methods once optimised and new high throughput screening methods will then allow 10,000 chemicals per day to be tested for toxicity. In the present project, firstly, novel gas chromatography x gas chromatography-time of flight-mass spectrometry (GCxGC-ToF-MS) methods will be used to separate, identify and measure, novel UCM compounds isolated from water soluble fractions of a range of crude oils; secondly, the same methods will be used to identify previously UCM toxicants in polluted mussels collected from a range of global locations. Thirdly, representatives of each compound class will be synthesised and toxicities assayed using mussel feeding rates, amphipod reproduction and growth rates and fish hepatocyte assays. Finally, the UCMs, newly resolved and identified in polluted mussels will be isolated and fractionated by preparative high performance liquid chromatography and their toxicities assayed, in an effects-directed approach. This will establish definitively the range of compounds in the UCMs that are toxic, and will deliver new methods by which UCMs may be routinely assayed and no longer overlooked. The major outcome of this investigation will be much improved assessment of the effects of organic chemical pollutants on the health of the global coastal marine environment
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Principal Investigator

Steven John Rowland (Prof.)

Host institution

UNIVERSITY OF PLYMOUTH

Address

Drake Circus
Pl4 8aa Plymouth

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 842 062

Principal Investigator

Steven John Rowland (Prof.)

Administrative Contact

John Martin (Dr.)

Beneficiaries (3)

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UNIVERSITY OF PLYMOUTH

United Kingdom

EU Contribution

€ 1 842 062

NORSK INSTITUTT FOR VANNFORSKNING

Norway

EU Contribution

€ 118 453,50

THE UNIVERSITY OF EXETER

United Kingdom

EU Contribution

€ 39 484,50

Project information

Grant agreement ID: 228149

Status

Closed project

  • Start date

    1 July 2009

  • End date

    31 December 2014

Funded under:

FP7-IDEAS-ERC

  • Overall budget:

    € 2 000 000

  • EU contribution

    € 2 000 000

Hosted by:

UNIVERSITY OF PLYMOUTH

United Kingdom