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Understanding the infection by the bacterium Listeria monocytogenes as a way to address key issues in biology

Objetivo

Host-pathogen interactions have recently received much attention. Yet, a more comprehensive understanding of these interplays should provide fundamental advances in biology and help generating new therapeutics. The intracellular bacterium Listeria monocytogenes has emerged as an exceptional model organism to address key questions in biology such as actin-based motility, phagocytosis and post-transcriptional regulation. We will exploit our deep knowledge of Listeria and use this bacterium as a model to explore new landmarks in biology.
In that aim, we will analyze several aspects of the infectious process, in a spatio-temporal fashion, at the bacteria, cell, tissue and host levels. Specifically, we will 1) search and analyze the function of new non-coding RNAs involved in virulence, and of new RNA-mediated regulations; 2) investigate new facets of bacterial entry and cell-to-cell spread in particular the role of uncharacterized cytoskeletal components, septins; 3) address the role of mitochondria and their dynamics in infection; 4) systematically analyze post-translational modifications during infection, starting with SUMOylation, a reversible modification and proteolysis, an irreversible one; 5) investigate chromatin remodeling upon infection; 6) characterize new virulence factors identified by their interaction with known signaling components or cellular sensors, by post genomics or by their effect on cellular responses analyzed herein ; 7) investigate further the intestinal phase of Listeria infection by analyzing in the germ-free transgenic mouse that we generated, the impact of commensals on Listeria (growth and transcription including non-coding RNAs) and on the intestinal tissue (histology and transcription of genes and microRNAs).
Our main goal is to improve significantly our understanding of bacterial infections, by discovering important new concepts in microbiology, cell biology and infection biology thereby opening new avenues for further research.

Convocatoria de propuestas

ERC-2008-AdG
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Régimen de financiación

ERC-AG - ERC Advanced Grant

Institución de acogida

INSTITUT PASTEUR
Dirección
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Francia
Tipo de actividad
Research Organisations
Aportación de la UE
€ 1 800 000
Investigador principal
Pascale Cossart (Prof.)
Contacto administrativo
Marie-Laure Rosso (Ms.)

Beneficiarios (1)

INSTITUT PASTEUR
Francia
Aportación de la UE
€ 1 800 000
Dirección
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Tipo de actividad
Research Organisations
Investigador principal
Pascale Cossart (Prof.)
Contacto administrativo
Marie-Laure Rosso (Ms.)