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MICRO MR Development of magnetic resonance measurement system for the examination characterisation and in vitro and in vivo observation of probes on a micrometer scale

MICRO MR Development of magnetic resonance measurement system for the examination characterisation and in vitro and in vivo observation of probes on a micrometer scale

Objective

The proposal will be aimed at the development of a magnetic tomography system for the examination of probes with submillimeter dimensions. Such applications are highly interesting for morphological and functional examinations of cellular systems and aggregates but also for in vivo applications even in humans of body cavities and by use of catheter intervention.

The crucial step of approaching sample diameters in the 10 500 mm range is the feasibility of building ultra small receiver coils with suitable microamplifiers for the efficient reception and acquisition of signals from such small samples. For imaging applications new principles of spatial encoding based on new designs for magnetic field gradients but also on other principles of spatial encoding are necessitated but also facilitated by the small sample dimensions. Using parallel acquisition techniques a multitude of such microcoils can be arranged in multicoil arrays either for the simultaneous acquisition of signals from multiple independent samples or if combined together for extremely fast imaging according to the principles of one coil one voxel OCOV imaging.

The objectives of the project will be to develop MicroMR systems which will be able to acquire magnetic resonance images and to monitor dynamic changes in cells cellular systems in vitro and in vivo microsystems of dimension Amp lt 500 micrometer with a spatial resolution of 0 1 10 microns by use of massively parallel microcoil arrays with dimensions of 50 500 micron coil to perform simultaneous NMR experiments on several hundred microprobes for use in Genomics Proteomics and Metabolomics use massively parallel microcoil arrays perform real time functional imaging of two dimensional structures microfilms biological samples skin etc.

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Coordinator

UNIVERSITAETSKLINIKUM FREIBURG FUER DIE MEDIZINISCHE FAKULTAET DER ALBERT LUDWIGS-UNIVERSITAET

Address

Hugstetter StraSSE 55
Freiburg

Germany

Administrative Contact

Klaus Juergen HENNIG (PROFESSOR)

Participants (4)

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THE ALBERT LUDWIGS UNIVERSITY FREIBURG

Germany

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

THE HENRYK NIEWODNICZANSKI INSTITUTE OF NUCLEAR PHYSICS POLISH ACADEMY OF SCIENCES

Poland

UNIVERSITY OF BASEL

Switzerland

Project information

Grant agreement ID: 28533

  • Start date

    1 February 2007

  • End date

    31 July 2010

Funded under:

FP6-POLICIES

  • Overall budget:

    € 1 799 992

  • EU contribution

    € 1 799 992

Coordinated by:

UNIVERSITAETSKLINIKUM FREIBURG FUER DIE MEDIZINISCHE FAKULTAET DER ALBERT LUDWIGS-UNIVERSITAET

Germany