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Determining Optimal non-invasive Parameters for the Prediction of Left vEntricular morphologic and functional Remodeling in Chronic Ischemic Patients

Determining Optimal non-invasive Parameters for the Prediction of Left vEntricular morphologic and functional Remodeling in Chronic Ischemic Patients

Objective

Coronary artery disease (CAD) remains the primary cause of cardiovascular morbidity and mortality in Europe. In current clinical practice, patients with chronic CAD are followed using non-invasive imaging methodologies for possible adverse morphologic remodelling and functional recovery of the myocardium before the decision for invasive examinations and treatments is taken. Technological developments have brought about several newer imaging methodologies (and associated parameters) that have shown accurate prognostic results under study conditions in selected patient populations. Each of these methodologies offers intrinsic advantages and disadvantages due to the physiologic processes it tries to assess, due to the technology it requires or due to its availability (often determined by its associated cost). However, to date, no large scale studies have made a direct comparison of the different methodologies towards predicting adverse morphologic remodelling or functional recovery of the myocardium after medical therapy. The lack of such information results in a sub-optimal use of the methodologies at hand. The aim of DOPPLER-CIP is therefore to conduct a multi-centre clinical study including about 1200 patients in order to determine the optimal prognostic parameters derived from (new) non-invasive imaging for a patient presenting with suspected chronic ischemic heart disease. The modality used to extract these parameters is of secondary importance. However, as both the accuracy and the cost related to extracting a particular parameter is modality-dependent, DOPPLER-CIP will also make a cost-effectiveness analysis in order to determine which modality should preferentially be used to extract the clinically most relevant parameter.
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Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN

Address

Oude Markt 13
3000 Leuven

Belgium

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 751 891,60

Administrative Contact

Elke Lammertyn (Ms.)

Participants (9)

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VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA

Finland

EU Contribution

€ 99 237,60

SERVICIO MADRILENO DE SALUD

Spain

EU Contribution

€ 183 152,40

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 159 184

KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST

United Kingdom

EU Contribution

€ 215 115

LINKOPINGS UNIVERSITET

Sweden

EU Contribution

€ 643 214,40

ADVANCED MEDICAL IMAGING DEVELOPMENT SRL

Italy

EU Contribution

€ 100 825,20

KING'S COLLEGE LONDON

United Kingdom

EU Contribution

€ 112 832,40

OSLO UNIVERSITETSSYKEHUS HF

Norway

EU Contribution

€ 287 090,40

UNIVERSITA DI PISA

Italy

EU Contribution

€ 62 454

Project information

Grant agreement ID: 223615

Status

Closed project

  • Start date

    1 May 2009

  • End date

    28 February 2015

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 426 433,80

  • EU contribution

    € 2 614 997

Coordinated by:

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium