CORDIS
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CORDIS

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Targeted delivery of dietary flavanols for optimal human cell function: Effect on cardiovascular health

Project information

Grant agreement ID: 226588

Status

Closed project

  • Start date

    1 September 2009

  • End date

    28 February 2013

Funded under:

FP7-KBBE

  • Overall budget:

    € 3 989 169,60

  • EU contribution

    € 2 999 195

Coordinated by:

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

Germany

Objective

Nutrition, i.e. our daily diet, is a major life style factor, greatly impacting on human health and disease. Epidemiological evidence suggests that diets rich in plant-based foods and beverages decrease the risk for cardiovascular morbidity and mortality. Various phytochemical constituents, in particular a class of compounds called flavanols, have been avidly investigated in recent years. Current dietary interventions in humans using flavanol-containing foods have substantiated epidemiological data indicating various potential dietary flavanol-mediated bioactivities, including improved vascular function, decreased blood pressure, attenuated platelet clotting, and improved immune responses. Latest innovations in flavanol analytics, chemistry, food processing technology, and cardiovascular function analysis make the elucidation of underlying mechanisms of flavanol bioactivity not just possible, but also impactful with regard to dietary advice and public health. Thus, a practical application of novel findings emanating from flavanol research in terms of a science/evidence-based development represents a worthwhile endeavour. This entails development of novel food ingredients, and innovative nutrient-delivery matrices. Such novel, nutritionally responsible food formulations hold the potential to open novel avenues in the prevention and amelioration of cardiovascular diseases in Europe. FLAVIOLA aims at: (i) illuminating the cellular and sub-cellular effects of flavanols and their main human metabolites; (ii) investigating key parameters of dietary flavanol absorption, clearance and efficacy towards surrogate markers of cardiovascular function in humans; (iii) developing innovative, functional, and nutritionally responsible food matrices for optimised dietary flavanol delivery; and finally (iv) demonstrating cardiovascular benefits and safety for a newly developed prototype food product.
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Coordinator

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

Address

Universitaetsstrasse 1
40225 Dusseldorf

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 600 800

Administrative Contact

Doris Neubert (Ms.)

Participants (7)

Mars Belgium

Belgium

EU Contribution

€ 311 460

THE UNIVERSITY OF READING

United Kingdom

EU Contribution

€ 589 410

UNIVERSITEIT MAASTRICHT

Netherlands

EU Contribution

€ 450 012

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT

France

EU Contribution

€ 299 842

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 299 840

UNIVERSITEIT GENT

Belgium

EU Contribution

€ 300 591

SCIPROM SARL

Switzerland

EU Contribution

€ 147 240

Project information

Grant agreement ID: 226588

Status

Closed project

  • Start date

    1 September 2009

  • End date

    28 February 2013

Funded under:

FP7-KBBE

  • Overall budget:

    € 3 989 169,60

  • EU contribution

    € 2 999 195

Coordinated by:

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

Germany

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