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Marine Metagenomics for New Biotechnological Applications

Marine Metagenomics for New Biotechnological Applications

Objective

The Project aims at the mining of individual enzymes and metabolic pathways from extremophilic marine organisms and the metagenomes from microbial communities from peculiar marine environments and consequent funnelling the new enzymatic reactions and processes towards the new biotechnological applications. Project builds up on the scientific and technological excellence of individual academic and industrial partners, and beyond that, on application of the state-of-the-art technologies for archiving, molecular screening for the activities (using a unique Surface Plasmon Resonance screening platform), protein structure elucidation, enzyme engineering and directed evolution and establishing new biotechnological processes (biocatalysis, synthesis of fine chemicals, etc.). Marine sampling hotspots to produce the metagenomic resources for their further exploration will cover the whole diversity of marine microbial life at its limits (hypersaline, low and high temperature, high pressure and low water activity conditions, etc.). Individual enzymes interacting with the substrates will be identified, and in case they are new, hyperexpressed and crystallized and their structures will be elucidated. Consequently, the most promising candidates will be scored against the chiral substrates of relevance for biocatalysis and their ability to perform in water-free systems will be evaluated, the directed evolution will be implemented to improve the performance, and specificity of the enzymes. A comprehensive bioinformatic survey throughout the whole tree of cellular life will reveal and suggest the new candidates homologous to the discovered new proteins, from other organisms to be cloned and assayed. The implementation of the set of new enzymes in the biotechnological processes for fine chemical synthesis and drug discovery will be conducted in a strong alliance with competent industrial partners.
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Coordinator

BANGOR UNIVERSITY

Address

College Road
Ll57 2dg Bangor

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 621 144

Administrative Contact

Dyfan Griffith (Mr.)

Participants (10)

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CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 357 549

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 366 858

HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

Germany

EU Contribution

€ 369 750

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 363 089

UNIVERSITE DE BRETAGNE OCCIDENTALE

France

EU Contribution

€ 369 828

THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

Canada

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 277 027

PHARMAMAR, S.A.

Spain

EU Contribution

€ 50 000

EVOXX TECHNOLOGIES GMBH

Germany

EU Contribution

€ 50 000

INSTITUT DE RECHERCHE PIERRE FABRESAS

France

EU Contribution

€ 50 000

Project information

Grant agreement ID: 226977

Status

Closed project

  • Start date

    1 July 2009

  • End date

    30 June 2013

Funded under:

FP7-KBBE

  • Overall budget:

    € 4 978 203

  • EU contribution

    € 2 875 245

Coordinated by:

BANGOR UNIVERSITY

United Kingdom

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