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RISK ASSESSMENT OF ENGINEERED NANOPARTICLES

RISK ASSESSMENT OF ENGINEERED NANOPARTICLES

Objective

Engineered Nanoparticles (ENP) are increasingly produced for use in a wide range of industrial and consumer products. Yet it is known that exposure to some types of particles can cause severe health effects. Therefore it is essential to ascertain whether exposure to ENP can lead to possible health risks for workers and consumers. We have formed a consortium of well-known scientists from European Universities and Research Institutes, with over 100 publications in the field of Nanotoxicology. Our aim is to develop an approach for the Risk Assessment of ENP (ENPRA). Our objectives are: (i) to obtain a bank of commercial ENP with contrasting physico-chemical characteristics and measure them; (ii) to investigate the toxic effects of ENP on 5 (pulmonary, hepatic, renal, cardiovascular and developmental) target systems and 5 endpoints (oxidative stress, inflammation; immuno-toxicity; fibrogenecity; genotoxicity) using in vitro animal/human models; (iii) to validate the in vitro findings with a small set of carefully chosen in vivo animal experiments; (iv) to construct mathematical models to extrapolate the exposure-dose-response relationship from in vitro to in vivo and to humans; (v) to use QSAR like models to identify the key ENP characteristics driving the adverse effects; (vi) to implement a risk assessment of ENP using the Weight-of-Evidence approach; (vii) to disseminate our findings to potential stakeholders. To harmonise the research activities between our EU group and the US, we have established links with scientists from US Universities (Duke, Rochester) and Government Agencies (NIH/NIEHS, NIOSH and EPA) with on-going research in Nanotoxicology. Our objectives here are (vii) to share information and agree on experimental protocols; (viii) to avoid duplication of work; (ix) to further validate the findings of this proposed study.
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Coordinator

INSTITUTE OF OCCUPATIONAL MEDICINE

Address

Research Avenue North, Riccarton 45
Eh14 4ap Edinburgh

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 400 680

Administrative Contact

Susy Scarisbrick (Ms.)

Participants (17)

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EDINBURGH NAPIER UNIVERSITY

United Kingdom

EU Contribution

€ 38 368

THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 217 810

UNIVERSITE PARIS DIDEROT - PARIS 7

France

EU Contribution

€ 200 726

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 168 298

UNIVERSITE CATHOLIQUE DE LOUVAIN

Belgium

EU Contribution

€ 194 889

KATHOLIEKE UNIVERSITEIT LEUVEN

Belgium

EU Contribution

€ 194 889

VRIJE UNIVERSITEIT BRUSSEL

Belgium

EU Contribution

€ 260 559

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

EU Contribution

€ 290 333

INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH

Germany

EU Contribution

€ 194 889

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 194 889

DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO

Denmark

EU Contribution

€ 271 300

UNIVERSITA CA' FOSCARI VENEZIA

Italy

EU Contribution

€ 286 025

JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION

Belgium

EU Contribution

€ 281 757

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU

Netherlands

EU Contribution

€ 351 402

UNIVERSITY OF ROCHESTER

United States

DUKE UNIVERSITY

United States

HERIOT-WATT UNIVERSITY

United Kingdom

EU Contribution

€ 153 186

Project information

Grant agreement ID: 228789

Status

Closed project

  • Start date

    1 May 2009

  • End date

    31 October 2012

Funded under:

FP7-NMP

  • Overall budget:

    € 5 269 000,66

  • EU contribution

    € 3 700 000

Coordinated by:

INSTITUTE OF OCCUPATIONAL MEDICINE

United Kingdom