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Integrated Micro-Nano-Opto Fluidic systems for high-content diagnosis and studies of rare cancer cells

Objectif

The project aims at developing a new integrated and automated microfluidic tool for cancer cells screening. This instrument will have a reliability and power much beyond state of the art (capture yield increased by a factor from 10X to 100X and multimodal typing of the cells in 3D high resolution images), allowing earlier and more accurate diagnosis, prognosis and selection of treatments of cancers. CaMiNEMS’s new approach will involve a new generation of bio-functionalised multifunctional magnetic nano and microparticles which will be self-assembled by a Hierarchial Templated Self-Assembly mechanism into high-aspect ratio reversible arrays. For highly automated molecular typing of cancers, this key innovation will be integrated with a unique fully automated flow control system working from nanolitres to millilitres and with innovative nano-optics tools and image analysis software. Technological developments will be validated regarding the analysis of circulating tumour cells or “micrometastases” and the molecular typing of minimally invasive microsamples from tumours. The project will also yield new tools for research and drug-discovery, allowing for the first time to study at the single molecule scale in single cancer cells from patients the fate and action of new generation anticancer drugs using innovative dynamic tracking of Quantum dots. To combine research excellence and societal impact, the consortium involves research groups with complementary competences in microfluidics, nano-optics, biophysics, nanoparticles, biochemistry, informatics, several forefront cancer centres for clinical validation and a research-intensive SME for exploitation.

Appel à propositions

FP7-NMP-2008-SMALL-2
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Coordinateur

INSTITUT CURIE
Adresse
Rue D'ulm 26
75231 Paris
France

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Type d’activité
Research Organisations
Contact administratif
Corinne Cumin (Ms.)
Contribution de l’UE
€ 847 533

Participants (8)

UNIVERZITA PARDUBICE
Tchéquie
Contribution de l’UE
€ 407 041
Adresse
Studentska 95
532 10 Pardubice

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Lucie Machacova (Ms.)
USTAV MAKROMOLEKULARNI CHEMIE AV CRVVI
Tchéquie
Contribution de l’UE
€ 395 540
Adresse
Heyrovsky Sq 2
162 06 Praha 6

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Type d’activité
Research Organisations
Contact administratif
Jan Kouba (Mr.)
FLUIGENT SA
France
Contribution de l’UE
€ 536 480
Adresse
57-77 Avenue De Fontainebleau
94270 Le Kremlin-bicetre

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Nicolas Guyot (Mr.)
IPATIMUP - INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP
Portugal
Contribution de l’UE
€ 193 082
Adresse
Rua Julio Amaral De Carvalho 45
4200 135 Porto

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Type d’activité
Research Organisations
Contact administratif
Ana Sofia Santos Silva (Dr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Contribution de l’UE
€ 453 983
Adresse
Wellington Square University Offices
OX1 2JD Oxford

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Chris Scotcher (Mr.)
INSTITUT GUSTAVE ROUSSY
France
Contribution de l’UE
€ 268 180
Adresse
Rue Camille Desmoulins 39
94805 Villejuif

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Type d’activité
Research Organisations
Contact administratif
Arnauld Forest (Mr.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Allemagne
Contribution de l’UE
€ 354 264
Adresse
Geschwister Scholl Platz 1
80539 Muenchen

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Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Christian Schindlbeck (Dr.)
AYMING
France
Contribution de l’UE
€ 95 040
Adresse
Rue Chaptal 114
92300 Levallois-perret

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Type d’activité
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contact administratif
Nicolas Marin (Mr.)