CORDIS
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CORDIS

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Integrated Micro-Nano-Opto Fluidic systems for high-content diagnosis and studies of rare cancer cells

Informations projet

N° de convention de subvention: 228980

État

Projet clôturé

  • Date de début

    1 Juillet 2009

  • Date de fin

    31 Decembre 2012

Financé au titre de:

FP7-NMP

  • Budget total:

    € 4 599 999,52

  • Contribution de l’UE

    € 3 551 143

Coordonné par:

INSTITUT CURIE

France

Objectif

The project aims at developing a new integrated and automated microfluidic tool for cancer cells screening. This instrument will have a reliability and power much beyond state of the art (capture yield increased by a factor from 10X to 100X and multimodal typing of the cells in 3D high resolution images), allowing earlier and more accurate diagnosis, prognosis and selection of treatments of cancers. CaMiNEMS’s new approach will involve a new generation of bio-functionalised multifunctional magnetic nano and microparticles which will be self-assembled by a Hierarchial Templated Self-Assembly mechanism into high-aspect ratio reversible arrays. For highly automated molecular typing of cancers, this key innovation will be integrated with a unique fully automated flow control system working from nanolitres to millilitres and with innovative nano-optics tools and image analysis software. Technological developments will be validated regarding the analysis of circulating tumour cells or “micrometastases” and the molecular typing of minimally invasive microsamples from tumours. The project will also yield new tools for research and drug-discovery, allowing for the first time to study at the single molecule scale in single cancer cells from patients the fate and action of new generation anticancer drugs using innovative dynamic tracking of Quantum dots. To combine research excellence and societal impact, the consortium involves research groups with complementary competences in microfluidics, nano-optics, biophysics, nanoparticles, biochemistry, informatics, several forefront cancer centres for clinical validation and a research-intensive SME for exploitation.
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Coordinateur

INSTITUT CURIE

Adresse

Rue D'Ulm 26
75231 Paris

France

Type d’activité

Research Organisations

Contribution de l’UE

€ 847 533

Contact administratif

Corinne Cumin (Ms.)

Participants (8)

UNIVERZITA PARDUBICE

Tchéquie

Contribution de l’UE

€ 407 041

USTAV MAKROMOLEKULARNI CHEMIE AV CRVVI

Tchéquie

Contribution de l’UE

€ 395 540

FLUIGENT SA

France

Contribution de l’UE

€ 536 480

IPATIMUP - INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVERSIDADE DO PORTO PCUP

Portugal

Contribution de l’UE

€ 193 082

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Royaume-Uni

Contribution de l’UE

€ 453 983

INSTITUT GUSTAVE ROUSSY

France

Contribution de l’UE

€ 268 180

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Allemagne

Contribution de l’UE

€ 354 264

AYMING

France

Contribution de l’UE

€ 95 040

Informations projet

N° de convention de subvention: 228980

État

Projet clôturé

  • Date de début

    1 Juillet 2009

  • Date de fin

    31 Decembre 2012

Financé au titre de:

FP7-NMP

  • Budget total:

    € 4 599 999,52

  • Contribution de l’UE

    € 3 551 143

Coordonné par:

INSTITUT CURIE

France