Skip to main content
European Commission logo print header

Design, synthesis and evaluation of selective met receptor kinase inhibitors as potential anticancer agents

Objective

The aim of this project is to combine molecular modeling with state-of-the-art medicinal chemistry methods to design and synthesise novel, selective, low molecular weight, substrate-like inhibitors of the MET tyrosine kinase. The Nottingham group is involved in the discovery of new agents that target cell-signaling pathways in order to develop rational chemotherapeutic strategies. Receptor protein kinases have been identified as potential new targets for drug design because of their involvement in cell signaling.

MET kinase is of particular interest, as it does not appear to be expressed in normal tissue thus minimizing the risks of a long-term kinase blockade strategy. To date most strategies aimed at receptor tyrosine kinases have involved blocking the ATP binding site and rely on exploiting differences between relatively well- conserved binding pockets to attain selectivity. The approach that will be taken here is different in that it is the substrate binding sites that will be targeted.

Topic(s)

Data not available

Call for proposal

IHP-MCIF-99-1
See other projects for this call

Funding Scheme

Data not available

Coordinator

THE UNIVERSITY OF NOTTINGHAM
EU contribution
No data
Address
University Park
NOTTIGHAM
United Kingdom

See on map

Total cost
No data