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Mechanistic Effect Models for the Ecological Risk Assessment of Chemicals

Mechanistic Effect Models for the Ecological Risk Assessment of Chemicals

Objective

There is widespread concern about how production and use of chemicals affect the environment. Yet food production and benefits of chemical products are vital for the functioning of European societies. In order to ensure sustainable use, EU regulations require extensive risk assessment before a chemical is approved for use. Current risk assessments focus on risk at the level of individual organisms, but according to EU directives the protection goal aims at achieving sustainable populations. Population-level effects depend not only on exposure and toxicity, but also on important ecological factors that are impossible to fully address empirically. Mechanistic effect models (MEMs) enable the integration of these factors, thus increasing the ecological relevance of risk assessments as well as providing vital understanding of how chemicals interact with ecosystems. Such understanding is crucial for improving risk mitigation strategies and ecosystem management. So far, however, regulators and industry have lacked understanding of the potential benefits that MEMs can deliver, and academics have been inconsistent in the approaches applied. This has led to scepticism about models, preventing a wider use of MEMs in risk assessment. Examples clearly demonstrating the power of MEMs for risk assessment are urgently needed, and industry, academia and regulatory authorities across Europe need scientists that are trained in both MEMs and regulatory risk assessment. CREAM will develop and experimentally validate a suite of MEMs for organisms relevant for chemical risk assessments. The consortium includes the main sectors involved (industry, academia, regulators) and will formulate Good Modelling Practice that will be followed in all individual projects, thus leading to consistency and transparency. CREAM will provide world class training for the next generation of ecological modellers, emphasizing transparency and rigorous model evaluation as core elements of the modelling process.
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Coordinator

HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ

Address

Permoserstrasse 15
04318 Leipzig

Germany

Activity type

Other

EU Contribution

€ 709 581,14

Administrative Contact

Annette Schmidt (Ms.)

Participants (13)

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ROSKILDE UNIVERSITET

Denmark

EU Contribution

€ 708 682,60

WAGENINGEN UNIVERSITY

Netherlands

EU Contribution

€ 374 737,50

RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN

Germany

EU Contribution

€ 394 408,79

EIDGENOESSISCHE ANSTALT FUER WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ

Switzerland

EU Contribution

€ 435 727

SYNGENTA LIMITED

United Kingdom

EU Contribution

€ 396 922,30

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU Contribution

€ 194 704,41

THE UNIVERSITY OF READING

United Kingdom

EU Contribution

€ 454 003,49

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

EU Contribution

€ 198 752,39

STICHTING VU

Netherlands

EU Contribution

€ 194 285,31

UNIVERSITY OF YORK

United Kingdom

EU Contribution

€ 415 904,99

UNIWERSYTET JAGIELLONSKI

Poland

EU Contribution

€ 305 931,99

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 239 373,21

VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

Netherlands

Project information

Grant agreement ID: 238148

Status

Closed project

  • Start date

    1 September 2009

  • End date

    31 July 2014

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 5 023 015,12

  • EU contribution

    € 5 023 015,12

Coordinated by:

HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ

Germany