CORDIS
EU research results

CORDIS

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Interplay of microbiota and gut function in the developing pig – Innovative avenues towards sustainable animal production

Project information

Grant agreement ID: 227549

Status

Closed project

  • Start date

    1 September 2009

  • End date

    31 August 2013

Funded under:

FP7-KBBE

  • Overall budget:

    € 3 966 108,60

  • EU contribution

    € 2 999 711

Coordinated by:

WAGENINGEN UNIVERSITY

Netherlands

Objective

Low input farming occurs under non-SPF (specific pathogen free) conditions. The European ban on in-feed antibiotics exposes the piglets to a higher microbial environmental pressure. The postnatal priming of piglets with a diverse microbiota may affect the development of the piglet’s host-defense and gut functionality. By reversal, the piglets developing host-defense may affect the development of the gastro-intestinal microbiota. Moreover, this intricate interplay between gut microbiota and its host during the early phases of life is expected to also affect animal health and performance later in life. The gut microbiome is an immensely diverse ecosystem that has co-evolved with its host. Recent research on microbe-host interactions has provided novel insights into the role of commensal intestinal microbes in several physiological processes, i.e., from epithelial barrier development to immune development as well as neurological aspects. Nevertheless, we only start to understand the molecular mechanisms of the host microbe cross-talk. Recent conceptual as well as technological advances have set the stage for the integrated application of a complementary set of high throughput approaches for the comprehensive profiling of GIT microbiota composition and functionality as well as the animal’s intestinal function. In a multidisciplinary consortium, comprising 11 public and private partners from across and beyond Europe with complementary expertise in gut microbiomics, immunology and physiology, and animal genomics and nutrition, INTERPLAY will apply an integrated approach to arrive at a sound understanding of the interaction of early colonization of the intestine and the development of gut function. This knowledge will be exploited for the identification of innovative management strategies that address host genotype as well as nutritional means to provide a framework for sustainable animal production at high food and consumer safety and improved animal health and welfare.
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Coordinator

WAGENINGEN UNIVERSITY

Address

Droevendaalsesteeg 4
6708 Pb Wageningen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 369 489

Administrative Contact

Jos Teunissen

Participants (12)

ID-LELYSTAD, INSTITUUT VOOR DIERHOUDERIJ EN DIERGEZONDHEID B.V.

Netherlands

EU Contribution

€ 88 535

ASG VEEHOUDERIJ BV

Netherlands

EU Contribution

€ 270 676

UNIVERSITY OF BRISTOL

United Kingdom

EU Contribution

€ 337 109

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT

France

EU Contribution

€ 495 244

OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG

Germany

EU Contribution

€ 276 000

ISTITUTO NAZIONALE DI RICERCA PER GLI ALIMENTI E LA NUTRIZIONE

Italy

EU Contribution

€ 222 000

NANJING AGRICULTURAL UNIVERSITY

China

EU Contribution

€ 117 600

PARCO TECNOLOGICO PADANO S.R.L.

Italy

EU Contribution

€ 239 640

MIKROBIOLOGICKY USTAV AV CR V.V.I

Czechia

EU Contribution

€ 102 800

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 275 418

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA

Italy

EU Contribution

€ 205 200

STICHTING WAGENINGEN RESEARCH

Netherlands

EU Contribution

€ 270 676

Project information

Grant agreement ID: 227549

Status

Closed project

  • Start date

    1 September 2009

  • End date

    31 August 2013

Funded under:

FP7-KBBE

  • Overall budget:

    € 3 966 108,60

  • EU contribution

    € 2 999 711

Coordinated by:

WAGENINGEN UNIVERSITY

Netherlands