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MAGNETIC NANOCONTAINERS FOR COMBINED HYPERTHERMIA AND CONTROLLED DRUG RELEASE

MAGNETIC NANOCONTAINERS FOR COMBINED HYPERTHERMIA AND CONTROLLED DRUG RELEASE

Objective

The aim of this project is the assembly and the fabrication of a new generation of multifunctional nanostructures for performing combined hyperthermia and controlled drug release, specifically targeted to cancer cells. The “magnetic nanocontainers” we intend to develop can perform at the same time cell recognition, hyperthermia treatment, and, as a consequence of the heat and /or cell environment stimuli, the release of drug with high selectivity for ovarian carcinoma. These multifunctional tasks are made possible due to the inclusion of three main components: a) the magnetic nanoparticles, allowing detection by MRI, cancer treatment by hyperthermia and providing stimuli for drug release; b) the nanocontainers, which allow for drug encapsulation and protection from degradation, facilitate the release of the drug upon application of an external stimulus, such as heat, or an internal one, such as the acidic pH of the tumour cells; c) the antibody fragments attached to the surface of the magnetic nanocontainers to deliver them selectively to the ovarian cancer cells. The individual building blocks and their assemblies will be characterized with respect to physical, chemical, and biological features, followed by dissemination of the newly acquired knowledge. Cell culture experiments will allow to understand the performance of such nano-tools in vitro. Directed towards application in patients, in vivo animal studies will be carried out on the most successful magnetic nanocontainers. The objectives of this proposal cover a wide range of scientific fields, hence a truly interdisciplinary collaboration between chemists, physicists, and biologists is required. To this end, we propose a european network collaboration between academic partners, who will take care of the development of new solutions for nanofabrication, and industrial partners implied in the field of the proposed application who will evaluate/develop the materials and act as advisors for risks arising during the project.

Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE

Address

Piazzale Aldo Moro 7
00185 Roma

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 373 707,25

Administrative Contact

Teresa Pellegrino (Dr.)

Participants (10)

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 648 103

UNIVERSITEIT TWENTE

Netherlands

EU Contribution

€ 351 840

Asociacion - Centro de Investigacion Cooperativa en Nanociencias - CIC NANOGUNE

Spain

EU Contribution

€ 239 416

DOMPE SPA

Italy

EU Contribution

€ 80 550

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Spain

EU Contribution

€ 225 772

UNIVERSIDAD COMPLUTENSE DE MADRID

Spain

EU Contribution

€ 151 417,75

FONDAZIONE IRCCS ISTITUTO NAZIONALE DEI TUMORI

Italy

EU Contribution

€ 395 020

NANOVECTOR SRL

Italy

EU Contribution

€ 295 200

MAGFORCE NANOTECHNOLOGIES AG

Germany

EU Contribution

€ 347 210

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Italy

EU Contribution

€ 327 720

Project information

Grant agreement ID: 228622

Status

Closed project

  • Start date

    1 September 2009

  • End date

    28 February 2013

Funded under:

FP7-NMP

  • Overall budget:

    € 4 859 982,14

  • EU contribution

    € 3 435 956

Coordinated by:

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

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