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The effects of antibiotic administration on the emergence and persistence of antibiotic-resistant bacteria in humans and on the composition of the indigenous microbiotas at various body sites

Objective

The objective of the HEALTH-2009-2.3.1-2 call is to study the impact of different antibiotics on the prevalence of resistant bacteria in the human host. In ANTIRESDEV we will achieve this objective using the approaches suggested in the call as follows. We will use culture-based and culture-independent approaches to investigate the impact of four different types of antibiotics (with different modes of action, antimicrobial spectra and pharmacokinetic properties) on the emergence of antibiotic-resistant organisms and their persistence at several body sites. Disruption of the indigenous microbiota is recognized as an important factor in the persistence and transmission of antibiotic-resistant organisms, therefore we will also study the ecological impact of the antibiotics on the indigenous microbiotas of several body sites using culture-dependent and -independent techniques. We will then identify, using state-of-the-art microarrays, the genes responsible for resistance in the antibiotic-resistant organisms isolated. The genetic elements involved in resistance transfer by a number of these organisms will also be determined as knowledge of these elements is essential to fully understand the mechanisms underlying resistance transmission. By using state-of-the-art 454 pyrosequencing we will determine the full complement of resistance genes (the “resistome”) present in cultivable and not-yet-cultivated members of the oral and faecal microbiotas and the effect on these resistomes of antibiotic administration. Another important aspect of the dynamics and transmission of resistance is the fitness cost associated with resistance acquisition by an organism and we will investigate this in a variety of clinically-important organisms. We will ensure that the results of this study are made available to appropriate governmental and healthcare agencies so that they can be used to help in the formulation of measures designed to reduce the spread of antibiotic resistance.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

University College London
Address
Gower Street
WC1E 6BT London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 882 060,75
Administrative Contact
Michael Wilson (Prof.)

Participants (10)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 575 520
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kim Von Schoultz (Mr.)
UNIVERSITA DEGLI STUDI DI SIENA
Italy
EU contribution
€ 300 000
Address
Via Banchi Di Sotto 55
53100 Siena
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gianni Pozzi (Prof.)
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 429 900
Address
Ramistrasse 71
8006 Zürich
Activity type
Other
Administrative Contact
Nadine Gina Mccallum (Dr.)
UNIVERSITAET BERN
Switzerland
EU contribution
€ 609 240
Address
Hochschulstrasse 6
3012 Bern
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vincent Perreten (Dr.)
ROBERT BOSCH GESELLSCHAFT FUR MEDIZINISCHE FORSCHUNG MBH

Participation ended

Germany
EU contribution
€ 59 871,47
Address
Auerbachstrasse 112
70376 Stuttgart
Activity type
Research Organisations
Administrative Contact
Cornelius Knabbe (Prof.)
Food and Environment Research Agency
United Kingdom
EU contribution
€ 700 312,50
Address
Area 1A, Nobel House, Smith Square 17
SW1P 3JR London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lucinda Cranham (Ms.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Netherlands
EU contribution
€ 359 035,20
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kasper Vries, De (Mr.)
Helperby Therapeutics Ltd
United Kingdom
EU contribution
€ 480 159,60
Address
Lincoln's Inn Fields
WC2A 3LH London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Anthony Coates (Prof.)
NEDERLANDSE ORGANISATIE VOOR TOEGEPAST NATUURWETENSCHAPPELIJK ONDERZOEK TNO
Netherlands
EU contribution
€ 565 064,75
Address
Anna Van Buerenplein 1
2595 DA Den Haag
Activity type
Research Organisations
Administrative Contact
John Hoebe (Mr.)
RUHR-UNIVERSITAET BOCHUM
Germany
EU contribution
€ 406 923,73
Address
Universitaetsstrasse 150
44801 Bochum
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Wibke Krahl (Ms.)