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Chromatin diseases: from basic mechanisms to therapy

Objective

The scope of this ITN is to promote research and training in the field of chromatin diseases. Chromatin diseases (CD) are genetic pathologies resulting from mutations in structural components of chromatin or in enzymes that biochemically modify chromatin, altering chromatin status and thereby causing drastic effects on gene expression. CD frequency ranges from very rare to quite common pathologies; so far for the vast majority of them no treatment is as yet available. Molecular studies on these pathologies thus have a twofold value: to shed light on the intricate interplays between different levels of control of gene expression acting in the mammalian nucleus and to pave the way toward new and more effective strategies to approach the treatment of this increasing class of diseases. Our students will take advantage of the integrated approach on multilayered gene regulation, the multidisciplinary nature and the cutting-edge methodologies, which are an integral part of this proposal. We thus expect to provide a framework for the very high-level training of young researchers, receiving a strong backgrounds in molecular, cellular and developmental biology, genomics, bioinformatics, chromatin biology and epigenetics. Furthermore, they will develop expertise in many cutting edge methodologies and tools, such as imaging, high throughput gene technologies, ChIP. As a result, the ESRs will be highly competitive in performing independent research in various areas of biology and will represent a new breed of scientists trained in contemporary post-genomic biology using advanced technological tools to tackle human disease.

Call for proposal

FP7-PEOPLE-ITN-2008
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Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE
Address
Piazzale Aldo Moro 7
00185 Roma
Italy

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Activity type
Research Organisations
Administrative Contact
Antonio Baldini (Prof.)
EU contribution
€ 564 827

Participants (10)

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

Participation ended

France
Address
Boulevard Charles Livon, Jardin Du Pharo 58
13284 Marseille

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Celine Damon (Ms.)
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Greece
EU contribution
€ 371 880
Address
Fleming Street 34
16672 Vari-athens

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Activity type
Research Organisations
Administrative Contact
George Kollias (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 219 751
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Edna Murphy (Ms.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 213 151
Address
Wellington Square University Offices
OX1 2JD Oxford

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lynne Hughson (Ms.)
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Spain
EU contribution
€ 380 355
Address
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat

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Activity type
Research Organisations
Administrative Contact
Victoria Cochrane (Ms.)
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italy
EU contribution
€ 212 351
Address
Via Universita 4
41121 Modena

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sebastiano Calandra Buonaura (Prof.)
UNIVERSITA DEGLI STUDI DELL'INSUBRIA
Italy
EU contribution
€ 205 751
Address
Via Ravasi 2
21100 Varese

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Adriana Jacona (Mr.)
UNIVERSITE D'AIX MARSEILLE
France
EU contribution
€ 206 452
Address
Boulevard Charles Livon 58 Le Pharo
13284 Marseille

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Celine Damon (Ms.)
DIAGENODE
Belgium
EU contribution
€ 200 309
Address
Rue Du Bois Saint Jean 3 Liege Park Science
4102 Seraing

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Leon Etienne (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health

Participation ended

United Kingdom
Address
Gower Street
WC1E 6BT London

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)