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Chromatin diseases: from basic mechanisms to therapy

Chromatin diseases: from basic mechanisms to therapy

Objective

The scope of this ITN is to promote research and training in the field of chromatin diseases. Chromatin diseases (CD) are genetic pathologies resulting from mutations in structural components of chromatin or in enzymes that biochemically modify chromatin, altering chromatin status and thereby causing drastic effects on gene expression. CD frequency ranges from very rare to quite common pathologies; so far for the vast majority of them no treatment is as yet available. Molecular studies on these pathologies thus have a twofold value: to shed light on the intricate interplays between different levels of control of gene expression acting in the mammalian nucleus and to pave the way toward new and more effective strategies to approach the treatment of this increasing class of diseases. Our students will take advantage of the integrated approach on multilayered gene regulation, the multidisciplinary nature and the cutting-edge methodologies, which are an integral part of this proposal. We thus expect to provide a framework for the very high-level training of young researchers, receiving a strong backgrounds in molecular, cellular and developmental biology, genomics, bioinformatics, chromatin biology and epigenetics. Furthermore, they will develop expertise in many cutting edge methodologies and tools, such as imaging, high throughput gene technologies, ChIP. As a result, the ESRs will be highly competitive in performing independent research in various areas of biology and will represent a new breed of scientists trained in contemporary post-genomic biology using advanced technological tools to tackle human disease.
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Coordinator

CONSIGLIO NAZIONALE DELLE RICERCHE

Address

Piazzale Aldo Moro 7
00185 Roma

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 564 827

Administrative Contact

Antonio Baldini (Prof.)

Participants (10)

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UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

France

BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING

Greece

EU Contribution

€ 371 880

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU Contribution

€ 219 751

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 213 151

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

Spain

EU Contribution

€ 380 355

UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA

Italy

EU Contribution

€ 212 351

UNIVERSITA DEGLI STUDI DELL'INSUBRIA

Italy

EU Contribution

€ 205 751

UNIVERSITE D'AIX MARSEILLE

France

EU Contribution

€ 206 452

DIAGENODE

Belgium

EU Contribution

€ 200 309

UNIVERSITY COLLEGE LONDON

United Kingdom

Project information

Grant agreement ID: 238242

Status

Closed project

  • Start date

    1 November 2009

  • End date

    31 October 2013

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 2 574 827

  • EU contribution

    € 2 574 827

Coordinated by:

CONSIGLIO NAZIONALE DELLE RICERCHE

Italy