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Chromatin diseases: from basic mechanisms to therapy

Obiettivo

The scope of this ITN is to promote research and training in the field of chromatin diseases. Chromatin diseases (CD) are genetic pathologies resulting from mutations in structural components of chromatin or in enzymes that biochemically modify chromatin, altering chromatin status and thereby causing drastic effects on gene expression. CD frequency ranges from very rare to quite common pathologies; so far for the vast majority of them no treatment is as yet available. Molecular studies on these pathologies thus have a twofold value: to shed light on the intricate interplays between different levels of control of gene expression acting in the mammalian nucleus and to pave the way toward new and more effective strategies to approach the treatment of this increasing class of diseases. Our students will take advantage of the integrated approach on multilayered gene regulation, the multidisciplinary nature and the cutting-edge methodologies, which are an integral part of this proposal. We thus expect to provide a framework for the very high-level training of young researchers, receiving a strong backgrounds in molecular, cellular and developmental biology, genomics, bioinformatics, chromatin biology and epigenetics. Furthermore, they will develop expertise in many cutting edge methodologies and tools, such as imaging, high throughput gene technologies, ChIP. As a result, the ESRs will be highly competitive in performing independent research in various areas of biology and will represent a new breed of scientists trained in contemporary post-genomic biology using advanced technological tools to tackle human disease.
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Coordinatore

CONSIGLIO NAZIONALE DELLE RICERCHE

Indirizzo

Piazzale Aldo Moro 7
00185 Roma

Italia

Tipo di attività

Research Organisations

Contributo UE

€ 564 827

Contatto amministrativo

Antonio Baldini (Prof.)

Partecipanti (10)

Classifica in ordine alfabetico

Classifica per Contributo UE

Espandi tutto

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

Francia

BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING

Grecia

Contributo UE

€ 371 880

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Regno Unito

Contributo UE

€ 219 751

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

Regno Unito

Contributo UE

€ 213 151

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE

Spagna

Contributo UE

€ 380 355

UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA

Italia

Contributo UE

€ 212 351

UNIVERSITA DEGLI STUDI DELL'INSUBRIA

Italia

Contributo UE

€ 205 751

UNIVERSITE D'AIX MARSEILLE

Francia

Contributo UE

€ 206 452

DIAGENODE

Belgio

Contributo UE

€ 200 309

UNIVERSITY COLLEGE LONDON

Regno Unito

Informazioni relative al progetto

ID dell’accordo di sovvenzione: 238242

Stato

Progetto concluso

  • Data di avvio

    1 Novembre 2009

  • Data di completamento

    31 Ottobre 2013

Finanziato da:

FP7-PEOPLE

  • Bilancio complessivo:

    € 2 574 827

  • Contributo UE

    € 2 574 827

Coordinato da:

CONSIGLIO NAZIONALE DELLE RICERCHE

Italia