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Chromatin diseases: from basic mechanisms to therapy

Obiettivo

The scope of this ITN is to promote research and training in the field of chromatin diseases. Chromatin diseases (CD) are genetic pathologies resulting from mutations in structural components of chromatin or in enzymes that biochemically modify chromatin, altering chromatin status and thereby causing drastic effects on gene expression. CD frequency ranges from very rare to quite common pathologies; so far for the vast majority of them no treatment is as yet available. Molecular studies on these pathologies thus have a twofold value: to shed light on the intricate interplays between different levels of control of gene expression acting in the mammalian nucleus and to pave the way toward new and more effective strategies to approach the treatment of this increasing class of diseases. Our students will take advantage of the integrated approach on multilayered gene regulation, the multidisciplinary nature and the cutting-edge methodologies, which are an integral part of this proposal. We thus expect to provide a framework for the very high-level training of young researchers, receiving a strong backgrounds in molecular, cellular and developmental biology, genomics, bioinformatics, chromatin biology and epigenetics. Furthermore, they will develop expertise in many cutting edge methodologies and tools, such as imaging, high throughput gene technologies, ChIP. As a result, the ESRs will be highly competitive in performing independent research in various areas of biology and will represent a new breed of scientists trained in contemporary post-genomic biology using advanced technological tools to tackle human disease.

Campo scientifico

  • /scienze mediche e della salute/medicina di base/patologia
  • /scienze naturali/scienze biologiche/biologia dello sviluppo
  • /scienze naturali/scienze biologiche/genetica ed ereditarietà/mutazione

Invito a presentare proposte

FP7-PEOPLE-ITN-2008
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Meccanismo di finanziamento

MC-ITN - Networks for Initial Training (ITN)

Coordinatore

CONSIGLIO NAZIONALE DELLE RICERCHE
Indirizzo
Piazzale Aldo Moro 7
00185 Roma
Italia
Tipo di attività
Research Organisations
Contributo UE
€ 564 827
Contatto amministrativo
Antonio Baldini (Prof.)

Partecipanti (10)

UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II

Partecipazione conclusa

Francia
Indirizzo
Boulevard Charles Livon, Jardin Du Pharo 58
13284 Marseille
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Celine Damon (Ms.)
BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING
Greece
Contributo UE
€ 371 880
Indirizzo
Fleming Street 34
16672 Vari-athens
Tipo di attività
Research Organisations
Contatto amministrativo
George Kollias (Dr.)
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Contributo UE
€ 219 751
Indirizzo
Trinity Lane The Old Schools
CB2 1TN Cambridge
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Edna Murphy (Ms.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Contributo UE
€ 213 151
Indirizzo
Wellington Square University Offices
OX1 2JD Oxford
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Lynne Hughson (Ms.)
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Spagna
Contributo UE
€ 380 355
Indirizzo
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Tipo di attività
Research Organisations
Contatto amministrativo
Victoria Cochrane (Ms.)
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italia
Contributo UE
€ 212 351
Indirizzo
Via Universita 4
41121 Modena
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Sebastiano Calandra Buonaura (Prof.)
UNIVERSITA DEGLI STUDI DELL'INSUBRIA
Italia
Contributo UE
€ 205 751
Indirizzo
Via Ravasi 2
21100 Varese
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Adriana Jacona (Mr.)
UNIVERSITE D'AIX MARSEILLE
Francia
Contributo UE
€ 206 452
Indirizzo
Boulevard Charles Livon 58
13284 Marseille
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Celine Damon (Ms.)
DIAGENODE
Belgio
Contributo UE
€ 200 309
Indirizzo
Rue Du Bois Saint Jean 3 Liege Park Science
4102 Seraing
Tipo di attività
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Leon Etienne (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health

Partecipazione conclusa

United Kingdom
Indirizzo
Gower Street
WC1E 6BT London
Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Greta Borg-Carbott (Ms.)