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European Obesity Consortium studying the Hypothalamus and its Interaction with Peripheral organs

European Obesity Consortium studying the Hypothalamus and its Interaction with Peripheral organs

Objective

The past decade has seen tremendous progress in our understanding of homeostatic regulators controlling energy balance. Insights from human and murine genetics have illuminated multiples pathways within the hypothalamus, brainstem and higher brain regions that play a key role in the control of food intake, whilst physiological studies focusing on the gastrointestinal tract have revealed a panoply of hormones that are secreted in response to or in anticipation of food intake and act centrally to regulate appetite. EurOCHIP brings together world leaders specializing in both areas in order to explore the interaction between the periphery and the brain in the control of energy homeostasis. Our programme of research will comprise four interdependent work-packages: i) characterising the interaction of gastrointestinal hormones with the hypothalamus and brainstem, with the aim of identifying novel molecules and pathways that mediate food intake; ii) using imaging techniques and behavioural phenotyping to explore the response of brain areas involved in higher cognitive and affective functions to these gastrointestinal hormones; iii) harnessing the power of human genetics to determine the role of sequence variation in and around newly identified candidate genes in appetitive behaviour and response to dietary interventions, focusing in particular on childhood obesity and iv) determining the effects of specific dietary interventions on gastrointestinal hormone secretion and using pharmacological studies in humans to mimic the hormonal milieu seen after a meal or bariatric surgery.
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Coordinator

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Address

Trinity Lane The Old Schools
Cb2 1tn Cambridge

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 546 666,11

Administrative Contact

Keith Cann (Mr.)

Participants (8)

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IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 387 440

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 387 440

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 387 560

KLINIKUM DER UNIVERSITAET ZU KOELN

Germany

EU Contribution

€ 387 640

DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE

Germany

EU Contribution

€ 172 289,14

GOETEBORGS UNIVERSITET

Sweden

EU Contribution

€ 387 400

EUROQUALITY SARL

France

EU Contribution

€ 128 345

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

EU Contribution

€ 215 215,75

Project information

Grant agreement ID: 241592

Status

Closed project

  • Start date

    1 October 2009

  • End date

    30 September 2013

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 854 510,04

  • EU contribution

    € 2 999 996

Coordinated by:

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom