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European Obesity Consortium studying the Hypothalamus and its Interaction with Peripheral organs

Objective

The past decade has seen tremendous progress in our understanding of homeostatic regulators controlling energy balance. Insights from human and murine genetics have illuminated multiples pathways within the hypothalamus, brainstem and higher brain regions that play a key role in the control of food intake, whilst physiological studies focusing on the gastrointestinal tract have revealed a panoply of hormones that are secreted in response to or in anticipation of food intake and act centrally to regulate appetite. EurOCHIP brings together world leaders specializing in both areas in order to explore the interaction between the periphery and the brain in the control of energy homeostasis. Our programme of research will comprise four interdependent work-packages: i) characterising the interaction of gastrointestinal hormones with the hypothalamus and brainstem, with the aim of identifying novel molecules and pathways that mediate food intake; ii) using imaging techniques and behavioural phenotyping to explore the response of brain areas involved in higher cognitive and affective functions to these gastrointestinal hormones; iii) harnessing the power of human genetics to determine the role of sequence variation in and around newly identified candidate genes in appetitive behaviour and response to dietary interventions, focusing in particular on childhood obesity and iv) determining the effects of specific dietary interventions on gastrointestinal hormone secretion and using pharmacological studies in humans to mimic the hormonal milieu seen after a meal or bariatric surgery.

Field of science

  • /medical and health sciences/basic medicine/medical genetics
  • /medical and health sciences/clinical medicine/surgery
  • /medical and health sciences/basic medicine/physiology/homeostasis
  • /natural sciences/biological sciences/genetics and heredity

Call for proposal

FP7-HEALTH-2009-single-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 546 666,11
Administrative Contact
Keith Cann (Mr.)

Participants (8)

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 387 440
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mike Robinson (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 387 440
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Administrative Contact
Gilles Pulvermuller (Mr.)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 387 560
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
Administrative Contact
Lyddie Laaland (Ms.)
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 387 640
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jutta Landvogt (Ms.)
DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE

Participation ended

Germany
EU contribution
€ 172 289,14
Address
Arthur-scheunert-allee 114-116
14558 Nuthetal
Activity type
Research Organisations
Administrative Contact
Judith Schaefer (Dr.)
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 387 400
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Margareta Ahlqwist (Dr.)
EUROQUALITY SARL
France
EU contribution
€ 128 345
Address
Rue De L Isly 8
75008 Paris 08
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Marc Ponsar (Mr.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 215 215,75
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Juergen Ertel (Dr.)