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Molecular Mechanisms of Cell Entry of Enveloped Viruses

Molecular Mechanisms of Cell Entry of Enveloped Viruses

Objective

Virus infections are a major cause of diseases and death among men and animals. The recent outbreak of SARS and the danger that an avian influenza virus may become pandemic, have clearly shown that members of any virus family can potentially turn into a pathogen. To combat virus infection and propagation, systematic and comprehensive studies both on viral components mediating virus-cell interactions, and on the cell biology behind virus entry are necessary. Our network, teaming academic and industrial groups, is aimed at undertaking an interdisciplinary effort to reveal the diversity of pathways and associated molecular mechanisms of cell entry of enveloped viruses. Research by experimental and theoretical approaches will be directed towards the identification of cellular receptors and of viral fusion proteins responsible for interaction with host cells. Among topics are folding, three-dimensional structure and conformational changes of viral fusion proteins as well as virus triggered signalling cascades in cells. Biophysical approaches will unravel the relationship between energetics of conformational changes of viral proteins and membrane bending and fusion. Together with industrial partners the project will identify potential targets for designed drug development, and will develop virus protein coated nanoparticles as new biotechnological and medical tools. The groups have complementary expertise at the highest standard in all required techniques of virology, molecular and cellular biology, biochemistry, proteomics, structural biology, theoretical and experimental biophysics. A challenging research and training environment in an international setting will provide young scientists with a network wide research-oriented training devoted to the specific aspects of virus entry and to structuring of industry projects and commercial exploitation of results, and a local training in soft skills and basic complementary education adapted to the personal needs.

Coordinator

HUMBOLDT-UNIVERSITAET ZU BERLIN

Address

Unter Den Linden 6
10117 Berlin

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 557 486

Administrative Contact

Ulrich Winderl (Mr.)

Participants (8)

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UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 809 040

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 240 341

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 401 904

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 454 486

TEL AVIV UNIVERSITY

Israel

EU Contribution

€ 424 700

INSTITUT PASTEUR

France

EU Contribution

€ 364 117

FREIE UNIVERSITAET BERLIN

Germany

EU Contribution

€ 393 807

Capsulution Pharma AG

Germany

EU Contribution

€ 199 102

Project information

Grant agreement ID: 235649

Status

Closed project

  • Start date

    1 October 2009

  • End date

    30 September 2013

Funded under:

FP7-PEOPLE

  • Overall budget:

    € 3 844 983

  • EU contribution

    € 3 844 983

Coordinated by:

HUMBOLDT-UNIVERSITAET ZU BERLIN

Germany